A new pyrimidine, 5-hydroxymethylcytosine (HMC) (1, 2), has been isolated from bacterial viruses of the T even type, which multiply in Escherichia coli. Deoxyriboside (3) and deoxyribotide (4) derivatives from this source have also been described. These components are not present in appreciable quantities in the nucleic acids of E. coli or of other cells, or in any other virus analyzed to date....

Olfaction presents the ultimate challenge to molecular recognition as thousands of molecules have to be recognized by far fewer olfactory receptors. We have presented evidence that Drosophila readily distinguish odorants based on their molecular vibrations using a battery of behavioral assays suggesting engagement of a molecular vibration-sensing component. Here we interrogate electrophysiologi...

Context. Despite the low cosmic abundance of deuterium (D/H ∼ 10−5), large degrees of deuterium fractionation in molecules are observed in star forming regions with enhancements that can reach 13 orders of magnitude, which current models have difficulties to account for. Aims. Multi-isotopologue observations are a very powerful constraint for chemical models. The aim of our observations is to u...

In presenting pyrimi-dine metabolism, most modern biochemistry texts contain a figure describing metabolism in bacterial cells and the alternative in animal cells. For plant biochemists, this discrepancy is disconcerting. Admittedly, py-rimidine metabolism has been largely overlooked in plants in favor of more glamorous endeavors. However, the importance of pyrimidines to almost all aspects of ...

Some novel annulated pyrido[2,3-d]pyrimidines 6 and 7 were synthesized stereoselectively by intramolecular hetero Diels-Alder reactions involving 1-oxa-1,3-butadienes.

A short sequential synthesis of pyrrolidino- pyridines and pyrimidines illustrates the potential of combining Ugi-Smiles couplings with radical tin-free processes.