BACKGROUND The growing tendency among opioid addicts to misuse multiple other drugs should lead clinicians and researchers to search for new pharmacological strategies in order to prevent life-threatening complications and minimize withdrawal symptoms during polydrug detoxification. METHODS A non-randomised, open-label in-patient detoxification study was used to compare the short-time efficac...

Herein, we show that a far-red arylidene-squaraine dye is stable against nucleophiles, in contrast to arene-squaraines. Owing to the fluorescence enhancement in apolar media together with high brightness and photostability, this dye was successfully applied to detect the oxytocin G protein-coupled receptor and monitor its internalization in living cells.

The dimeric η(6)-hexamethylbenzene ruthenium(II) triazole compounds of formulation [{(η(6)-C(6)Me(6))Ru(N(3)C(2)(CO(2)R)(2))}(2)(μC(2)O(4))] have been synthesized by 1,3-diploar cycloadditions of coordinated azido compound [{(η(6)-C(6)Me(6))Ru(L(1))N(3)}] (1) with substituted acetylene, RO(2)CC(2)CO(2)R via unexpected oxidation of the coordinated ligand to oxalate (where; L(1) = 5-hydroxy-2-(hy...

Cofacial Fe2, Co2, and Ni2 complexes supported by a para-terphenyl diphosphine ligand were prepared. Central arene deplanarization and a μ2:(η(3),η(3)) coordination mode suggest partial bisallyl character in the Fe2 and Co2 complexes. An oxidation induced shift in Fe2-arene binding highlights the non-innocent nature of the arene ligand.

The in vitro activity of a series of ruthenium clusters, [(g-C6H6)(g -C6Me6)2 Ru3(l-H)3(l3-O)][BF4], [(g -C6H6)(g -1,4-PrC6H4Me)(g -C6Me6)Ru3(l-H)3(l3O)][BF4], [(g -C6H6)4Ru4(l-H)4][BF4]2, [(g -C6H5Me)4Ru4(l-H)4][BF4]2 and [(g-C6H6)4Ru4(l-H)3(l-OH)][Cl]2, has been evaluated against A2780 and A2780cisR ovarian carcinoma cell lines. Both triruthenium clusters are very active compared to ruthenium...

The liver fulfills many vital functions for the body, among them bile formation and detoxification. Bile salts are organic anions, major constituents of at high concentrations cytotoxic. Detoxification exposes to harmful compounds. This function is therefore potentially damaging liver. Impaired may lead hepatic accumulation subsequently disease. Diagnosis diseases involves measurement so-called...

Chronic benzodiazepine (BDZ) abuse is currently treated with detoxification using a low-dose flumazenil infusion, a relatively recently developed and promising procedure. Given the possibility reported in the literature of the occurrence of generalized seizures during therapeutic BDZ detoxification, we usually administer preventive antiepileptic drug (AED) therapy. We describe two patients with...

In 2009, pyrethroid resistance was confirmed for seven "annual bluegrass weevil" Listronotus maculicollis Kirby (Coleoptera: Curculionidae) adult populations from southern New England. The mechanisms responsible for conferring this resistance were unknown. In this study, topical application bioassays with bifenthrin and bifenthrin combined with synergists affecting three detoxification systems ...

BACKGROUND General practitioners are referring patients with codeine-related problems to specialist treatment facilities, but little is known about the addiction treatment providers, the kinds of treatment they provide, and whether training or other interventions are needed to strengthen this sector. OBJECTIVES To investigate the perspectives of addiction treatment providers regarding treatme...