Our goal is to optimize regularized image reconstruction for emission tomography with respect to lesion detectability in the reconstructed images. We consider model observers whose decision variable is the maximum value of a local test statistic within a search area. Previous approaches have used simulations to evaluate the performance of such observers. We propose an alternative approach, wher...

A good placement of sensors is crucial to get good performance in detecting and isolating faults. Here, the sensor placement problem is cast as a minimal cost optimization problem. Previous works have considered this problem with qualitative detectability and isolability specifications. A key contribution here is that quantified detectability and isolability performance is considered in the opt...