نتایج جستجو برای: depth profiling
تعداد نتایج: 242779 فیلتر نتایج به سال:
Recent developments in FT—IR sampling techniques such as diffuse reflectance and photoacoustic spectroscopy are known to obtain new and novel information on solid polymers. In particular, depth profiling can be obtained from the surface using a potassium bromide overlayer. Photoacoustic spectroscopy using coupling gases with different polarizability allows one to determine the nature of absorbe...
To the Editor: Agurs-Collins et al. (1) recently analyzed data from the 2013 US Health Information National Trend Survey (HINTS) concerning the levels of public awareness of Direct-to-Consumer genetic testing (DTC-GT), the factors associated with public awareness of DTC-GT, and the main sources of information about testing. They reported that more than one third of citizens were aware of DTC-GT...
The bombardment of a 26 nm poly(methyl methacrylate) (PMMA) film has been studied as a model for depth profiling of polymeric samples using a newly developed C60 þ ion source. Experiments were conducted on a ToF-SIMS instrument equipped with C60 þand Gaþ ion sources. A focused dc C60 þ ion beam was used to etch through the polymer sample at specified time intervals. Subsequent spectra were reco...
A molecular multilayer stack composed of alternating Langmuir-Blodgett films was analyzed by ToF-SIMS imaging in combination with intermediate sputter erosion using a focused C60+ cluster ion beam. From the resulting dataset, depth profiles of any desired lateral portion of the analyzed field-of-view can be extracted in retrospect, allowing the influence of the gating area on the apparent depth...
It is common for the components in a homogeneous metallic alloy to separate at its surface. This phenomenon is known as surface segregation. For example, under certain conditions, the surface layer of atoms in a Cu85Pd15 is pure copper, while the second layer of atoms is 50% copper. The bulk retains its 85/15 composition. A depth-profile characterizes the surface segregation by describing the a...
We report on application of pulsed photothermal radiometry (PPTR) to determine the depth of port wine stain (PWS) blood vessels in human skin. When blood vessels are deep in the PWS skin (>100 microm), conventional PPTR depth profiling can be used to determine PWS depth with sufficient accuracy. When blood vessels are close or partially overlap the epidermal melanin layer, a modified PPTR techn...
Although re-sequencing of gene panels and mRNA expression profiling are now firmly established in clinical laboratories, in-depth proteome analysis has remained a niche technology, better suited for studying model systems rather than challenging materials such as clinical trial samples. To address this limitation, we have developed a novel and optimized platform called SP3-Clinical Tissue Prote...
BACKGROUND Further advances of targeted cancer therapy require comprehensive in-depth profiling of somatic mutations that are present in subpopulations of tumor cells in a clinical tumor sample. However, it is unclear to what extent such intratumor heterogeneity is present and whether it may affect clinical decision-making. To study this question, we established a deep targeted sequencing platf...
Cluster secondary ion mass spectrometry (cluster SIMS) has played a critical role in the characterization of polymeric materials over the last decade, allowing for the ability to obtain spatially resolved surface and in-depth molecular information from many polymer systems. With the advent of new molecular sources such as C(60)(+), Au(3)(+), SF(5)(+), and Bi(3)(+), there are considerable increa...
RATIONALE In order to determine the degree of cross-linking on the surface and its variations in a nanometer-scale depth of organic materials, we developed an approach based on time-of-flight secondary ion mass spectrometry (TOF-SIMS), which provides rich chemical information in the form of fragment ions. TOF-SIMS is extremely surface-sensitive and capable of depth profiling with the use of a s...
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