INTRODUCTION Oxytocin (OT) is a well-known neuropeptides which together with vasopressin, melatonin, insulin and other hormones can alter both behavior and physiological or neuronal functions. This growing interest on OT roles is also based on the demonstrated beneficial effects as a stress reliever and a social bonding agent. The association between old age and OT was only vaguely studied. Lit...

The synaptogenic hypothesis of major depressive disorder implies that preventing the onset depressive-like behavior also prevents loss hippocampal spine synapses. By applying psychoactive drugs, diazepam and fluoxetine, we investigated whether blocking development helpless by promoting stress resilience in rat learned helplessness paradigm is associated with a synaptoprotective action hippocamp...

It is now clear that positive emotion leads to enhanced psychological functioning. What is less clear, however, is just why this is so. Drawing on a social-functional perspective, we argue that positive emotional behavior that accurately signals to others the individual's internal state will enhance social connectedness. Positive emotional behavior that does not accurately signal a person's exp...

background non-diagnosed depression might postpone the physical healing of patients and negatively affects prognosis. the rate of major depressive disorder among patients of general practitioners in the united states reaches 10 percent and among patients admitted to the inner wards reaches 15 percent. patients and methods a cross sectional study on physician of two hospitals was performed. a qu...

Background: Chronic stress-induced depressive-like behavior is relevant to inflammatory immune activation. However, the neurobiological alterations in the brain following the central inflammatory immune activation remain elusive. Methods: Therefore, we investigated the neurobiological alterations during depressive-like behavior induced in mice by systemic administration of lipopolysaccharide (L...