Concerns have recently been raised about a possible link between suicidal ideation and the use of SSRIs in teenagers diagnosed with unipolar depression, such that the USA FDA and UK CSM have issued warnings regarding the use of SSRIs in adolescents with depression. We investigated this phenomenon first by recognizing that the initial presentation of unipolar and bipolar depression may only diff...

OBJECTIVE The authors sought to determine the association between treatment for generalized anxiety disorder and the risk of major depression among adults in the community. METHOD Data were drawn from the National Comorbidity Survey (N=8,098), a representative sample of the United States population age 15-54. Cox proportional hazards were used to determine the association between specific for...

BACKGROUND Ritualistic behaviors are common in obsessive compulsive disorder (OCD), while catatonic stupor occasionally occurs in psychotic or mood disorders. Schizoaffective disorder is a specific mental disorder involving both psychotic and affective symptoms. The syndrome usually represents a specific diagnosis, as in the case of the 10th edition of the International Classification of Diseas...

BACKGROUND The relative contribution of demographic, lifestyle and medication factors to the association between affective disorders and cardiometabolic diseases is poorly understood. AIMS To assess the relationship between cardiometabolic disease and features of depresion and bipolar disorder within a large population sample. METHOD Cross-sectional study of 145 991 UK Biobank participants:...

The current subtyping of depression is based on the Diagnostic and Statistical Manual of Mental Disorders, 4th ed, Text Revision (DSM-IV-TR) categorical division of bipolar and depressive disorders. Current evidence, however, supports a dimensional approach to depression, as a continuum/spectrum of overlapping disorders, ranging from bipolar I depression to major depressive disorder. Types of d...

There has been an increase in research on the topic of psychedelic substances and their effects as treatment options neuropsychiatric conditions. Psilocybin is a drug that recently garnered increased interest effective modality for treatment-resistant depression, depression associated with terminal conditions, certain substance use disorders, obsessive-compulsive disorder. However, sparse data ...

OBJECTIVE A decline in hypothalamic-pituitary-gonadal (HPG) axis function is often seen in elderly men, and dysthymic disorder is common. Symptoms of both HPG axis hypofunction and dysthymic disorder include dysphoria, fatigue, and low libido. The authors compared total testosterone levels in three groups of elderly men. METHOD Total testosterone levels were measured in subjects who met DSM-I...

The efficacy and safety of pramipexole have been reported both in the treatment unipolar/bipolar depression anxiety/depression patients with Parkison disease. But, there is no evidence for its clinical effect seasonal depressive disorder. In this case report, patient responded to presented.

BACKGROUND Family members of patients in intensive care are at increased risk for psychological symptoms. OBJECTIVES To compare levels of posttraumatic stress disorder, anxiety, and depression during and 3 months after the intensive care experience in family members of patients at high risk for dying and to determine if differences were related to the patient's final disposition. METHODS Lo...