16 cases of affective disorder were studied. 8 patients received carbamazepine and 8 received either chlorpromazine or imipramine. Ratings were carried out on the Hamilton Rating Scale for Depression, Bech Rafaelsen Mania Rating scale and a side-effects symptom check list. Garbamazepine was found to be an effective treatment for affective disorders, possessing both anti-manic as well as anti-de...

This article traces the history of the Khat which is an intoxicant and also a sexual depressant. The author establishes that its origion is Abyssinia and it is brought to Arabia where it is commonly used even by Muslims. If Khat is consumed in excess it may impair the health but moderate quantity is beneficial.

Gisekia Pharnaceoides Linn is a diffuse subsucculent, glabrous herb. It is aromatic, aperient and act as powerful anthelmintic in cases of taenia. The plant possesses antibacterial, CNS depressant and anthelmintic activity. The present communication deals with the morphology, anatomy, microscopic constants, Physicochemical constants preliminary phytochemical studies and fluorescence Linn.

The mechanism of sepsis-induced cardiac failure was initially thought to be related to the presence of 'myocardial depressant' substances that directly alter heart function. Exosomes released by platelets and identified in the plasma are suggested to, at least partially, explain myocardial depression in sepsis. This hypothesis needs to be evaluated by clinical studies.

Jieyu chufan (JYCF) is a well-known Chinese traditional medicine used for depression; however, the molecular mechanism underlying its anti-depressant action has remained elusive. In the present study, the anti-depressant effects of JYCF and the potential mechanisms were investigated in a mouse model. Five groups of 12 C57BL/6 mice each were used in the study, including a normal control group (N...

CONTEXT Depression, a sustained mood disorder caused by selective diminution of specialized cells in brain is increasing at an alarming rate. It will be the second largest morbid illness by next decade and is the leading cause of suicidal deaths. The available antidepressant medications benefit only a third of its recipients and have many side effects. Hence, it is imperative to search in Ayurv...

The present study investigated the ability of a number of presynaptic snake neurotoxins (snake beta-neurotoxins) to produce nerve-evoked train-of-four fade, tetanic fade and endplate potential run-down during the development of neuromuscular blockade in the isolated mouse phrenic-hemidiaphragm nerve-muscle preparation. All the snake beta-neurotoxins tested, with the exception of notexin, produc...