background: perfectionism appears to play an important role in the etiology, maintenance, and course of psychological disorders. however, very few clinical data exist to clarify the nature and the relationship between dimensions of perfectionism with depression and anxiety.   objective: the aim of this study was to compare dimensions of perfectionism in depressed and anxious patients.   methods...

Drug abuse is prevalent in all countries across the world and  induces variety of adverse effects (1). Health problems arising from drug abuse commonly cause significant health challenges in the affected population and deteriorate many aspects of the patients’ performance and quality of life. Comorbidities are discovered in 60 to 75% of addict patients, suffering from various drug-related disor...

the wisconsin test card sorting test (wcst) is a neuropsychological test that has been suggested as a more specific test for frontal lobes dysfunctions. this study was designed to determine whether wcst is able to differentiate between iranian psychiatric patients with cognitive disorders and normal subjects, and whether wcst scores are related to severity of symptoms in depressive and schizoph...

Background: Attention deficit hyperactivity disorder and conduct disorder are among relatively prevalent disorders during childhood and adolescence. Considering the negative impact of the parents' drug dependency and bipolar disorder, the present study aimed to determine the prevalence of ADHD and conduct disorder in children of drug-dependent and bipolar parents. Methods: In this case-control ...

This phase I, open-label, single-dose study evaluated the pharmacokinetics, safety, and tolerability of renally excreted drug dexpramipexole in subjects with normal and impaired renal function, i.e. mild, moderate, severe renal impairment, or end-stage renal disease (ESRD) requiring hemodialysis when matched by age and sex. Dexpramipexole area under the curves (AUCs), but not Cmax , were signif...

we investigated the association between serum 25(oh) d levels and depressive symptoms in patients with major depressive disorder (mdd).eighty-five adults, 44 drug free patients with mdd and 41 apparently healthy controls, participated in the study. the hamilton depression rating scale was used to assess severity of major depression. mental health of the controls was assessed according to dsm-iv...