INTRODUCTION Synthesis in the field of nucleic acids has been a major and continuing interest in my laboratory ever since we knew the structures of the nucleic acids. Clearly the foundations of synthetic work in the nucleotide field were laid by the prolonged and intensive efforts of Professor Todd's laboratory (Cambridge, England) and it was my good fortune to be associated with this laborator...

,g i:. The contemporary biochemist, perusing the publications of the past century, may easily be misled into some arrogance when sorting out the erroneous data and leads, the slow progress and the primitive reports of that early period. However, when recalling the limited techniques and the lack of facilities at the early stages of biochemistry, he will change his mind. The difficulties encount...

THE ROLE OF THYMONUCLEIC ACID IN NORMAL CELLS Chromosomes and Genes Cytoplasmic Nucleic Acids Protein Synthesis Bacteria and Filterable Viruses THE ROLE OF THYMONUCLEIC ACID IN NEOPLASTIC CELLS The Significance of Nucleic Acids in the Somatic Mutation Theory of Etiology Chemical Evidence of Disturbance of Nucleic Acids in Tumors Histochemical and Cytochemical Evidence of Disturbance of Thymonuc...