During an electron microscopic study of experimental demyelination, many variations in the contour of the myelin sheath were observed in normal guinea pig sciatic nerves. These variations consisted of loops and folds of compact myelin which indented the axoplasm or protruded into the Schwann cell cytoplasm. Depending on the plane of section they were seen as isolated ovoids of myelin within axo...

Experimental allergic encephalomyelitis (EAE) 1 has been widely studied as a possible experimental model for human demyelinative diseases, the two most common of which are multiple sclerosis and acute disseminated encephalomyelitis. EAE is also the only experimental autoimmune disease for which the exact amino acid sequence of an inciting molecule, basic protein of myelin, is known (1). Nearly ...

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Anti-ganglioside (anti-GM1) antibodies have been implicated in the pathogenesis of Guillain-Barré syndrome, multifocal motor neuropathy and motor neuron diseases. It has been held that they may interfere with saltatory conduction by blocking sodium channels. We tested this hypothesis by analysing action potentials from 140 single nerve fibres in 22 rat ventral roots using external longitudinal ...

BACKGROUND The etiology of multiple sclerosis (MS) has remained unclear, but a causative contribution of factors outside the central nervous system (CNS) is conceivable. It was recently suggested that gut bacteria trigger the activation of CNS-reactive T cells and the development of demyelinative disease. METHODS C57BL/6 (B6) mice were kept either under specific pathogen free or conventional ...

introduction : eating disorders are serious psychiatric illness, defined by abnormal eating behaviors, shape and weight regulation difficulties and weight over concern.  objectives: this study sought to explore the prevalence and intensity of anorexia nervosa, bulimia nervosa, binge eating and their sub-thresholds in women who referred to wellness and fitness centers. materials and methods: 946...

conclusions according to the results of the current study, living with family members has positive effects on mental health and other mental processes of adolescents. results according to the results of the current study, there was a significant relationship between the girl students living in boarding high schools and their peers in regular high schools in the aggression, anxiety, and depressi...

conclusions the results of this study provide information about the prevalence of minor psychiatric disorder among nurses, and factors, which affect the prevalence of such disorders. these findings can be used in strategic planning processes to improve nurses’ mental health. results the prevalence of minor psychiatric disorder among nurses was estimated to be 27.5%. gender and sleep disorders w...