نتایج جستجو برای: demyelination

تعداد نتایج: 5277  

Journal: :Journal of virology 2011
G D Ghadge R Wollmann G Baida M Traka R P Roos

The DA strain and other members of the TO subgroup of Theiler's murine encephalomyelitis virus (TMEV) induce an early transient subclinical neuronal disease followed by a chronic progressive inflammatory demyelination, with persistence of the virus in the central nervous system (CNS) for the life of the mouse. Although TMEV-induced demyelinating disease (TMEV-IDD) is thought to be immune mediat...

Background: The hippocampus, a vital center for learning and memory, is extremely vulnerable to neurological diseases.Several reports of cognitive and memory impairment have been published in patients with Multiple sclerosis (MS). The prevalence of MS is highest where environmental supply of vitamin D is low. In the present study spatial working memory and reference memory after treatment with ...

2018
Nellie A. Martin Viktor Molnar Gabor T. Szilagyi Maria L. Elkjaer Arkadiusz Nawrocki Justyna Okarmus Agnieszka Wlodarczyk Eva K. Thygesen Miklos Palkovits Ferenc Gallyas Martin R. Larsen Hans Lassmann Eirikur Benedikz Trevor Owens Asa F. Svenningsen Zsolt Illes

Background The cuprizone (CPZ) model of multiple sclerosis (MS) was used to identify microRNAs (miRNAs) related to in vivo de- and remyelination. We further investigated the role of miR-146a in miR-146a-deficient (KO) mice: this miRNA is differentially expressed in MS lesions and promotes differentiation of oligodendrocyte precursor cells (OPCs) during remyelination, but its role has not been e...

Journal: :Journal of virology 1995
M Rodriguez K Pavelko R L Coffman

Administration of neutralizing monoclonal antibody to gamma interferon increased Theiler's virus-induced demyelination and virus antigen persistence in the spinal cord in susceptible SJL/J mice and completely abrogated resistance such that all C57BL/10SNJ mice developed demyelination. These experiments support the hypothesis that gamma interferon is critically important for resistance to Theile...

Journal: :Neurochemistry International 2019

Journal: :Journal of Histochemistry & Cytochemistry 1968

ali hemmati, ali reza, hatami, homeira, khezri, shiva, nejati, faranak,

Background & Objectives: Demyelination by Ethidium bromide is one of the ways that is usually used for preparing experimental models of MS. Treatment with estrogen protects oligodendrocyts from cell poisoning and stops lipidic peroxidation. The aim of this study is the evaluation of the effects of estrogen on anxiety like behavior and stress oxidative parameters after inducing demyelination by ...

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