Angiotensin II and atrial natriuretic peptide (ANP) play important and opposite roles in the control of water and salt intake, with angiotensin II promoting the intake of both and ANP inhibiting the intake of both. Following blood volume expansion, baroreceptor input to the brainstem induces the release of ANP within the hypothalamus that releases oxytocin (OT) that acts on its receptors in the...

Recurrent GBM (RGBM) has a highly unfavorable prognosis with majority of patients dying within 6 months and no standard treatments available. Antineoplaston (ANP) A10 and AS2-1 injections underwent Phase II trials in RGBM patients, which reported a long-term overall survival (OS) in a small percentage of patients. The additional Phase II studies BT-07, and BT-21 with ANP in GBM also revealed ca...

A major competitive advantage of production and service systems is establishing a proper maintenance policy. Therefore, maintenance managers should make maintenance decisions that best fit their systems. Multi-criterion decision-making methods can take into account a number of aspects associated with the competitiveness factors of a system. This paper presents a multi-criterio...

Maximizing shareholders’ value has always been an indispensable goal for publicly traded companies. Shareholders value is highly dependent on the operating expenses, profit margin, return on investment and the overall performance in public companies. We propose a hybrid fuzzy multi-criteria decision making method for measuring the performance of publicly held companies in the Pharmaceutical ind...

Important elements for the success of the PROMETHEE methods have been the development of numerous extensions and interactive software. The purpose of the paper is to show the evolution of the PROMETHEE methods and of their software implementation over time. Starting with PROMCALC and the first visual sensitivity analysis tools (Walking Weights), we stress less known extensions of the methodolog...

The detection and governmental punitive agency is responsible for supervision on correct implementation of the business laws in Iran. Several criteria are involved in performance assessment of detection and governmental punitive agency. The interaction between criteria and sub-criteria may occur in real situations. Moreover, the performance measurement should be accomplished in a multi-period h...