Dysregulation of transforming growth factor-β1 (TGF-β1) and insulin-like growth factor (IGF) axis has been linked to reactive stroma dynamics in prostate cancer progression. IGF binding protein-3 (IGFBP3) induction is initiated by stroma remodeling and could represent a potential therapeutic target for prostate cancer. In previous studies a lead quinazoline-based Doxazosin® derivative, DZ-50, i...

Aging phenomena in the plastic response of amorphous solids are studied within the theory of shear transformation zones (STZs), which describes the kinetic rearrangement of localized defects in response to external stress. To account for the slow, nonequilibrium dynamics after a quench below the glass transition temperature, two possible models are considered. In the first model, transition rat...

Average vertical attenuation coefficients, K(av), for irradiance calculated by linear regression of ln E(z) on z through the euphotic zone or from two irradiance values in a certain depth interval, are useful but somewhat arbitrary procedures for estimating these important apparent optical properties of the ocean. A more fundamental approach is to calculate an irradiance-weighted coefficient, K...

Ligands acting at the benzodiazepine (BZ) site of g-aminobutyric acid type A (GABAA) receptors currently are the most widely used hypnotics. BZs such as diazepam (Dz) potentiate GABAA receptor activation. To determine the GABAA receptor subtypes that mediate the hypnotic action of Dz wild-type mice and mice that harbor Dz-insensitive a1 GABAA receptors [a1 (H101R) mice] were compared. Sleep lat...

-Elongated shapes of garnets in high-grade metamorphic rocks have been explained as a result of plastic crystal flow or anisotropic growth. In the case of lowto medium-grade metamorphic rocks, a satisfactory explanation has not been proposed yet for elongated garnets. We have studied elongated garnets grown under lowgrade metamorphic conditions in a shear zone with a composite planar-linear fab...

Our team tested the hypothesis that pharmacological induction of ischemicpreconditioning can offer cytoprotection and preserve vital tissues after hemorrhagicshock and stroke. The compound, diazoxide (DZ), is known to induce preconditioningthrough its effect as a mitochondrial KATP channel opener and succinate dehydrogenaseinhibitor. When DZ was administered 24 hours prior to sh...

Nar-infrared fluorescence (NIRF) dyes have recently emerged as promising tools for non-invasive imaging of different types of cancers. Heree, we explored the potential utility of a NIRF DZ-1 dye, with dual imaging and tumour targeting functions, in hepatocellular carcinoma (HCC). We showed the preferential uptake of DZ-1 by HCC cells in vitro and in derived subcutaneous/orthotopic tumour xenogr...

The massive sulphide deposit at Kantienpan Cu-Zn mine is hosted by volcano sedimentary succession known as the Areachap Group, in the eastern part of Namaqua Metamorphic Province, South Africa. The deposits were affected by a complex deformation and metamorphic history and represent examples of upper amphibolite to granulite grade metamorphosed volcanic-hosted m...

The brittle portion of the Earth’s lithosphere contains a distribution of joints, faults and cataclastic zones that exist on a wide range of scale-lengths and usually have complex geometries including bends, jogs, and intersections. The material around these complexities is subjected to large stress concentrations, which lead during continuing deformation to the generation of new fracture and g...