نتایج جستجو برای: defensin 126
تعداد نتایج: 20324 فیلتر نتایج به سال:
Nikolinka ANTCHEVA*, Francesca MORGERA*, Luisa CREATTI*, Lisa VACCARI†, Ulrike PAG‡, Sabrina PACOR*, Yechiel SHAI§, Hans-Georg SAHL‡ and Alessandro TOSSI*1 *Department of Life Sciences, University of Trieste, Giorgieri Street 1, 34127 Trieste, Italy, †ELETTRA Synchrotron Light Laboratory, Area Science Park, 34012 Basovizza, Trieste, Italy, ‡Institute for Medical Microbiology, Immunology and Par...
BACKGROUND A key issue in the treatment of periprosthetic joint infection (PJI) is the correct diagnosis. The main problem is lack of diagnostic tools able to diagnose a PJI with high accuracy. Alpha-defensin has been proposed as a possible solution, but in the current literature, there is a lack of independent validation. QUESTIONS/PURPOSES We performed a prospective study to determine (1) w...
Helicobacter pylori exhibits tropism for the human stomach causing a spectrum of complications ranging from gastritis to gastric cancer in susceptible individuals. The mechanism(s) that allow the bacteria to persist and cause disease are unfolding, p-defensins are a family of endogenous, epithelial anti-microbial peptides that engage in host defense most prominently at mucosal surfaces. We and ...
In this article, we introduce and apply our de novo protein design framework, which observes true backbone flexibility, to the redesign of human beta-defensin-2, a 41-residue cationic antimicrobial peptide of the innate immune system. The flexible design templates are generated using molecular dynamics simulations with both Generalized Born implicit solvation and explicit water molecules. These...
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