ObjectiveTo study the molecular mechanisms involved in appearance of fibrotic trait endometriosis by investigating whether signaling pathway bioactive sphingolipid sphingosine 1-phosphate (S1P) was altered endometriotic lesions.DesignCase-control laboratory study.SettingUniversity research institute and university hospital.Patient(s)A total 75 women, with without endometriosis, were included st...

STUDY QUESTION Are protein oxidative stress markers [thiols, advanced oxidation protein products (AOPP), protein carbonyls and nitrates/nitrites] in perioperative peritoneal fluid higher in women with histologically proven endometriosis when compared with endometriosis-free controls? SUMMARY ANSWER Protein oxidative stress markers are significantly increased in peritoneal fluids from women wi...

BACKGROUND The G protein-coupled estrogen receptor (GPER) is thought to be involved in non-genomic estrogen responses as well as processes such as cell proliferation and migration. In this study, we analyzed GPER expression patterns from endometriosis samples and normal endometrial tissue samples and compared these expression profiles to those of the classical sex hormone receptors. METHODS A...

Background: To identify and safeguard the ureters of patients with deep infiltrating endometriosis or complex pelvic adhesion (obliterated cul-de-sac) using indocyanine green (ICG) during laparoscopic surgery. Methods: Stepwise surgical demonstration narrated video footage. The stepwise procedures were: (1) Explore abdominal cavity, resect adhesions, remove right ovarian endometrioma cysts, ope...

Deep-infiltrating endometriosis may affect the vagina, the rectum, and the cervicoisthmic part of the uterus, resulting in severe pain, particularly dyschezia, dysmenorrhea, dyspareunia, and diminished quality of life. Advanced surgical techniques, such as laparoscopic-assisted anterior rectum resection, are recognized as safe and effective therapeutic approaches. In some cases, a laparotomy or...

BACKGROUND The purpose of this paper is to report the long-term results of surgery without bowel resection in patients suffering from deep infiltrating endometriosis with rectovaginal or colorectal involvement. METHODS This retrospective observational study identified 42 patients suffering with deep infiltrating endometriosis who underwent surgery. Conservative surgery was performed in 23 wom...