Analysis of deep brain stimulation and ablative lesions in surgical treatment of movement disorders With emphasis on safety aspects

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Dopamine dysregulation syndrome is a complication of the dopaminergic treatment in Parkinson's disease that may be very disabling due to the negative impact that compulsive medication use may have on patients' social, psychological, and physical functioning. The relationship between subthalamic nucleus deep brain stimulation and dopamine dysregulation syndrome in patients with Parkinson's disea...

BACKGROUND Symptomatic peri-lead edema is a rare complication of deep brain stimulation that has been reported to develop 4 to 120 days postoperatively. CASE PRESENTATION Here we report the case of a 63-year-old Hispanic man with an 8-year history of Parkinson's disease who underwent bilateral placement of subthalamic nucleus deep brain stimulation leads and presented with acute, symptomatic,...

Herrington TM, Cheng JJ, Eskandar EN. Mechanisms of deep brain stimulation. J Neurophysiol 115: 19–38, 2016. First published October 28, 2015; doi:10.1152/jn.00281.2015.—Deep brain stimulation (DBS) is widely used for the treatment of movement disorders including Parkinson’s disease, essential tremor, and dystonia and, to a lesser extent, certain treatment-resistant neuropsychiatric disorders i...

deep brain stimulation (dbs) is a neurosurgical procedure that enables brain structures to be stimulated electrically by a pacemaker implanted under the skin. in the 1980s, over a decade after its first use in pain, implantable dbs of the thalamus was performed to suppress tremor in parkinson’s disease (pd) refractory to drug treatments. primate-based research soon afterwards identified the sub...

“Inductively Coupled Deep Brain Stimulator” describes a chip/system design to inductively couple arbitrary waveforms to electrodes embedded in the brain for deep brain stimulation or other neurostimulation. This approach moves the conventionally implanted signal generator outside the body and provides flexibility in adjusting waveforms to investigate optimum stimulation waveforms. An “inlaid el...