BACKGROUND Pseudomonas aeruginosais a frequent nosocomial pathogen that causes severe diseases in many settings. Carbapenems, including meropenem and imipenem, are effective antibiotics against this organism. However, the use of carbapenems has been hampered by the emergence of strains resistant to carbapenemsvia different mechanisms such as the production of metallo-β-lactamases (MBLs), which ...

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The aim of this study was to determine the usefulness of the MPC of carbapenems against clinical isolates of Pseudomonas spp. and Acinetobacter spp. and to assess its possible relationship with mechanisms of resistance. Detection of the mechanisms of resistance was performed using Antibiotic Susceptibility Testing, Double Disk Synergy, disk antagonism, addition of NaCl to the medium, addition o...

Short period double degenerates (DDs) are close white dwarf –white dwarf binary stars which are the result of the evolution of interacting binary stars. We present the first definitive measurements of the mass ratio for two DDs, WD0136+768 and WD1204+450, and an improved measurement of the mass ratio for WD0957−666. We compare the properties of the 6 known DDs with measured mass ratios to the p...

Background and Objectives New Delhi metallo-ß-lactamase (NDM) is a newly emerging metallo-ß-lactamases, which can destroy all β-lactams including carbapenems. Therefore, this study aimed at evaluating New Delhi metallo-ß-lactamase-1-production in clinical isolates of Klebsiella pneumoniae in Kashan, Iran. Materials and Methods In a cross-sectional study, 181 K. pneumoniae isolates were collec...

Introduction: Any bacterial isolates showing resistant to three or more than different types of antimicrobial groups are termed as multidrug resistant. Such superbugs have shown significant challenge not only microbiologist but also clinicians. Multidrug like extended-spectrum and metallo-beta lactamase being encountered the causative agents blood stream infection. Accurate diagnosis infection,...

background : these days, the antibiotic resistance of pseudomonas aeruginosa isolates to imipenem has significantly increased. therefore the study of resistance to imipenem in this organism to imipenem in determining the appropriate treatment is crucial and necessary. the goal of this study is to compare three phenotypic methods of e-test, disk diffusion and micro broth dilution in the study of...

Purpose: To investigate the distribution of plasmid-encoded extended spectrum beta-lacatamases (ESBLs) in Lahore, Pakistan using different phenotypic and molecular methods. Methods: Escherichia coli and Klebsiella spp were obtained over a period of nineteen months (June 2007 to December 2008). Both were tested by the double disk synergy test, combined disk test and Epsiometer-test (E-test) to e...

Klebsiella pneumoniae is a pathogen relevant to hospital acquired and community such as urinary tract infections, pneumonia, wound burn. It has high levels of antibiotic resistance capability produce biofilm. This study included comparing among six patterns for the detected biofilm gene (mrkA). Clinical samples were collected from Teach Bagubah Hospital, Al-Batool Maternity Children Teaching pr...

The emergence of plasmid mediated extended spectrum b-lactamases (ESBLs) in members of family Enterobacteriaceae has become a worldwide problem. Many clinical microbiology laboratories make no effort to detect ESBL production by Gram negative bacilli and have problem to detect ESBL mediated resistance. The choice of optimal laboratory method for detection and surveillance of ESBL producing orga...