Abstract Graft versus host disease (GVHD) is the major and often lethal complication of allogenic bone marrow transplantation. Prophylactic regimens for GVHD are given as standard pre-transplantation therapy; however, up to 60% these patients develop GVHD, require additional immunosuppressive intervention. We identified a probiotic exopolysaccharide (EPS) that induces inhibitory macrophages tol...

Overenthusiastic repair of damaged blood vessels could cause a fatal blockage. Sedding et al. (page 2801) report that the normal repair-restricting function of factor VII activating protease (FSAP) is disrupted by a common mutation. People carrying the mutation might thus be more at risk of vessel narrowing. Approximately 5% of the population carries an FSAP polymorphism linked to cardiovascula...

acute myeloid leukemia (aml) is a type of poor prognosis hematological malignancies characterized by heterogeneous clonal expansion of myeloid progenitors. leukemic stem cells are thought to form the majority of a cell population in minimal residual diseases (mrds) which are resistant to current chemotherapeutic regimens and mediate disease relapse. current therapeutic vaccine strategies have d...

background: t helper 1 and t helper 17 cells play important roles in immunity against foreign invaders. differentiation of these th subsets is affected by state of maturation and cytokines that are produced by dendritic cells (dcs). curdlan is a linear (1→3)-β- glucan and has shown activity against tumors and infectious agents. objective: this study aims to investigate whether curdlan plays its...

Vibrio parahaemolyticus, the cause of gastroenteritis in humans, was inactivated by alternating low-amperage electricity. In this study, the application of alternating low-amperage electric treatment to effluent seawater was investigated for the large-scale disinfection of seawater. This method was able to overcome the problem of chlorine generation that results from treatment with continuous d...

Abstract Introduction TIPE-2 has been identified as a negative regulator of both innate and adaptive immunity is involved in several inflammatory diseases. However, the role immune suppression dendritic cells (DCs) transduced with not well studied. Methods In this study, DCs were recombinant adenovirus, then cocultured allogeneic CD4+ or CD8 + T cells. The proliferation, cytokine production act...

Dendritic cells (DCs) are the master regulators of T cell recirculation, according to a study by Mora et al. on page 303. Memory T cells—thought to be programmed to return to the location in which they first encountered antigen—can be rerouted by an encounter with a DC from another location. Previous studies have shown that memory T cells express a characteristic array of adhesion molecules and...