the objective of this study was to investigate whether or not the adverse effects of heat on sperm quality could be prevented by green tea extract (gte) administration. ninety adult male mice were randomly divided to two groups. the scrotum of each animal in the first group was immersed once for 20 min in a water bath maintained at 42 oc (heat group, h) and the second group (control group, c) w...

the virulence of pasteurella multocida (p. multocida) serotype a1 for chickens and mice was determined. groups of chicken and mice were exposed intramuscularly and intraperitoneally to various concentration of p. multocida broth culture, respectively. this strain was highly virulent for chickens so that those exposed to only 7 c.f.u. of the organism died in less than 24 hours. groups of mice ex...

objective(s):  there is a rising use of gold nanoparticles (aunps) in goods and in the medical fields but there is concern about the toxicity of them. so in this study spherical aunps with 3 different concentrations were applied for investigating their effects in vivo.   materials and methods:  40 male albino mice were randomly divided into sham, control, 25 ppm, 50 ppm, 100 ppm groups and were...

the effects of cholecystokinin (cck) receptor antagonists on hypothermia induced by cocaine or morphine have been studied in mice. in the present work, subcutaneous (sc) injection of cocaine (50-150 mg/kg) or morphine (125-500 mg/kg) induced hypothermia in mice. administration of ccka receptor antagonist mk-329 (0.5-1.5 mg/kg), cckb receptor antagonist l-365, 260 (0.5-1.5 mgl kg) and cck recept...

paraquat (pq) is a widely used herbicide. however, a large number of cases of accidental or suicidal poisoning from pq has been reported. membrane damage induced by lipid peroxidation, inactivation of protein or damage to dna by radical formation have been suggested as toxicity mechanisms of pq. in the present work, the effects of atropine, propranolol, procainamide and dipyridamole on pq-induc...

background: methotrexate (mtx) is an anti-metabolite drug widely used in treatment of neoplastic disorders, rheumatoid arthritis and psoriasis. the ester derivative, ethyl pyruvate (ep) is stable in solution and should function as an antioxidant and energy precursor. this study was conducted to evaluate the protective role of ep on sperm parameters, testosterone level and malondialdehyde (mda) ...

objective(s) cannabinoids have been implicated in memory deficit. we examined the effect of am281, cannabinoid antagonist/inverse agonist in prevention of scopolamine-induced cognitive deficit. materials and methods  object recognition task was used to evaluate memory in mice. exploration time in the first and the second trial was recorded. the differences in exploration between a previously se...

the immune responses of mice immunized with ovalbumin (ova) together with killed l. major (klm) promastigotes as adjuvant were studied. three doses (5 × 107, 1 × 108 and 2 × 108) of klm combined with ova (100 mg) were injected into the groups of c57bl/6 mice. bcg and complete freund’s adjuvant (cfa) were used as control adjuvants. lymphocyte proliferation and antibody titers were determined, an...

vampirolepis nana is the most common cestode in humans especially children. domestic mice and rats can serve as definitive hosts for v. nana. confusion exists over the species status and host-specificity of this tapeworm. in a previous study done by the same authors it was found that the egyptian human isolates of v. nana could be used to infect mice for experimental work. eggs in human feces a...

b ackground: animal models with various combination of host-parasite have long been employed to study malaria pathogenesis. here, we describe the combination of plasmodium berghei anka infec- tion in inbred icr mice as a model of cerebral malaria (cm). m ethods: infection in mice was initiated by intraperitoneal injection of 2 x 107  (0.2ml) parasitized red blood cells (prbcs). r esults: this m...