A combination of emetine hydrochloride with chloroquine yields better results than either drug alone in the treatment of amoebic liver abscess in adults (Wilmot, Powell, and Adams, 1959). A similar combination of dehydroemetine with chloroquine is equally satisfactory (Wilmot, Powell, MacLeod, and Elsdon-Dew, 1964; Powell, Wilmot, MacLeod, and Elsdon-Dew, 1967). Dehydroemetine is claimed to be ...

Defining a consistent technique for maintaining the positive definiteness of the matrices generated by quasi-Newton methods for equality constrained minimization remains a difficult open problem. In this paper, we review and discuss the results obtained with a new technique based on an extension of the Wolfe line-search used in unconstrained optimization. The idea is to follow a piecewise linea...