Two highly environmentally contrasting localities on either side of the Isthmus of Panama were chosen to investigate the response of zooid size to differing seasonal regimes within colonies of cupuladriid bryozoans. The Bocas del Toro region in the southern Caribbean experiences a very low mean annual range of temperature (MART) while, as a result of seasonal upwelling, the Gulf of Panama in th...

During the past several years, many enterprises have created data warehouses (and data marts) in order to run applications. Data warehousing technologies used have been primarily extract-transform-load (ETL) tools, database modeling and design tools, and relational database (RDB) systems. There are three major holes in data warehousing today. These include inadequate attention to dirty data, in...

Structured Abstract Purpose-This paper evaluates the comparative progress of Asda in the UK since its surprise takeover by Wal-Mart in 1999. Wal-Mart expected to become the #1 retailer in the UK and many commentators saw massive problems ahead for local retailers. These expectations were not met; this paper investigates why. Design/Methodology/Approach-Asda's progress is considered through a br...

This paper summarizes the development of a data mining solution for business intelligence applied to the channel detail in a soft drink industry. The aim is to develop the analysis, design and construction of a solution based on the guidelines on the CRISP-DM methodology. The solution of business intelligence used has a data mart with consolidate information, which allows users to quickly acces...

Data warehouse is now widely used in business analysis and decision making processes. To adapt the rapidly changing business environment, we develop a tool to make data warehouses more business-friendly by using Semantic Web technologies. The main idea is to make business semantics explicit by uniformly representing the business metadata (i.e. conceptual enterprise data model and multidimension...

Non-linear models recently receive a lot of attention as people are starting to discover the power of statistical and embedding features. However, tree-based models are seldom studied in the context of structured learning despite their recent success on various classification and ranking tasks. In this paper, we propose S-MART, a tree-based structured learning framework based on multiple additi...

Adoptive cell transfer (ACT) of ex vivo engineered autologous lymphocytes encoding high-affinity MART-1/HLA-A*0201-specific T-cell receptor (TCR)α/β chains (F5 CTL), densely infiltrate into sites of metastatic disease, mediating dramatic but partial clinical responses in patients with melanoma. We hypothesized that MART-1 downmodulation in addition to aberrant apoptotic/survival signaling could...

Adoptive cell transfer (ACT) of ex vivo engineered autologous lymphocytes encoding high-affinity MART-1/HLA-A 0201–specific T-cell receptor (TCR)a/b chains (F5 CTL), densely infiltrate into sites of metastatic disease, mediating dramatic but partial clinical responses in patients with melanoma. We hypothesized that MART-1 downmodulation in addition to aberrant apoptotic/survival signaling could...

Both @I@+and (@4@ T cells have demonstrated roles in antitumor Immune response in many animal tumor systems. In many human tumor systems, although abundant literature exists on the evidence of tumor antigen-specific CD8@CTh response, only limited information is available on tumor antigen-specific CD4' T-cell response. Using the MART-l/ Melan-A (MART-i) antigen system as a prototype human tumor-...

PURPOSE The purpose of this study was to determine the toxicity and immunological effects of three different doses and two routes of administration of autologous dendritic cells (DCs) pulsed with the MART-1(27-35) immunodominant epitope. EXPERIMENTAL DESIGN Eighteen HLA-A*0201-positive subjects with stage III-IV melanoma received three biweekly i.v. or intradermal injections of ex vivo genera...