نتایج جستجو برای: dast 5
تعداد نتایج: 1215906 فیلتر نتایج به سال:
Cytosine can undergo modifications, forming 5-methylcytosine (5-mC) and its oxidized products 5-hydroxymethylcytosine (5-hmC), 5-formylcytosine (5-fC) and 5-carboxylcytosine (5-caC). Despite their importance as epigenetic markers and as central players in cellular processes, it is not well understood how these modifications influence physical properties of DNA and chromatin. Here we report a co...
The Ten-eleven translocation (TET) proteins have been recently identified as critical regulators in epigenetic modification, especially in the methylation of cytosine in DNA. TET-mediated DNA oxidation plays prominent roles in a wide variety of physiological and pathological processes, especially in tumor and neural development. TET proteins execute stepwise enzymatic conversion of 5-methylcyto...
We present a chemical method to selectively tag and enrich thymine modifications, 5-formyluracil (5-fU) and 5-hydroxymethyluracil (5-hmU), found naturally in DNA. Inherent reactivity differences have enabled us to tag 5-fU chemoselectively over its C modification counterpart, 5-formylcytosine (5-fC). We rationalized the enhanced reactivity of 5-fU compared to 5-fC via ab initio quantum mechanic...
The absolute levels of 5-hydroxymethylcytosine (hmC) and 5-methylcytosine (mC) in human brain tissues at various ages were determined. Additionally, absolute levels of 5-formylcytosine (fC) in adult individuals and cytosine modification levels in sorted neurons were quantified. These data were compared with age-related fC, hmC, and mC levels in mouse brain samples. For hmC, an initial steady in...
این پژوهش با هدف کلی مطالعه انطباق ساختار پنج عاملی شخصیت مرضی (PSY-5) با محور دوم DSM-5 در قالب یک پژوهش پیمایشی پرسشنامهای انجام گرفته است. پژوهش از جمله مطالعات روششناسی و آزمونسازی به حساب میآید. در این تحقیق ابتدا حمایت تجربی دادههای ایرانی برای ساختار پنج عاملی شخصیت مرضی (PSY-5) و ساختار عاملی صفات و حیطههای کلی شخصیت DSM-5 مطالعه شدند. سپس همخوانی بین مقیاسهای شخصیت مرضی (PSY-5) ...
AIM The concurrent, construct and discriminative validity of the World Health Organization's Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) were examined in a multi-site international study. PARTICIPANTS One thousand and 47 participants, recruited from drug treatment (n = 350) and primary health care (PHC) settings (n = 697), were administered a battery of instruments. M...
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