Vaccinia virus (VACV) encodes an innate immune evasion protein, E3, which contains an N-terminal Z-nucleic acid binding (Zα) domain that is critical for pathogenicity in mice. Here we demonstrate that the N terminus of E3 is necessary to inhibit an IFN-primed virus-induced necroptosis. VACV deleted of the Zα domain of E3 (VACV-E3LΔ83N) induced rapid RIPK3-dependent cell death in IFN-treated L92...

OBJECTIVE Our study uses data from a large clinical trial to further dissect the contributors attitude toward antipsychotic medication measured with the Drug Attitude Inventory (DAI) in schizophrenia. METHOD A total of 227 consecutive outpatients (140 males, 87 females) with schizophrenia or schizoaffective disorder according to DSM-IV criteria were evaluated. Structural equation models (SEM)...

Abstract: This study examines how the historical state conditions long-run development, using Vietnam as a laboratory. Northern Vietnam (Dai Viet) was ruled by a strong, centralized state in which the village was the fundamental administrative unit. Southern Vietnam was a peripheral tributary of the Khmer (Cambodian) Empire, which followed a patronclient model with more informal, personalized p...

Gaps in digital accessible information (DAI) on species distributions hamper prospects of safeguarding biodiversity and ecosystem services, and addressing central ecological and evolutionary questions. Achieving international targets on biodiversity knowledge requires that information gaps be identified and actions prioritized. Integrating 157 million point records and distribution maps for 21,...

Human-animal interaction (HAI) supports a theory that animals may enhance social support both directly, as a source of comfort, and indirectly, as a facilitator of human interaction. Existing research found that dogs are suitable in helping children develop healthy self-esteem and empathy for others and the classroom interaction between assistance dogs and children is also effective in developi...

R.D. Sochol, A.T. Higa, R.R.R. Janairo*, S. Li†, L. Lin‡ Department of Mechanical Engineering, Berkeley Sensor and Actuator Center, University of California, Berkeley, CA, USA 668 Sutardja Dai Hall, Berkeley, CA 94720, USA Joint Graduate Group in Bioengineering, University of California, Berkeley & University of California, San Francisco, CA, USA Department of Bioengineering, University of Cali...

Department of Mechanics of Materials, School of Mechanical Engineering, Hanoi University of Science and Technology, No. 1, Dai Co Viet Road, Hanoi, Viet Nam b International Research Center for Computational Materials Science, Hanoi University of Science and Technology, No. 1, Dai Co Viet Road, Hanoi, Viet Nam Department of Engineering Science and Mechanics, M/C 0219, Virginia Polytechnic Instit...

1 Institute for Molecular and Cellular Biology, Osaka University, 1-3 Yamada-oka, Suita, Osaka 565-0879, Japan 2 Genomic Sciences Center, RIKEN, c/o Laboratory of Genome Database, Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokane-dai, Minato-ku, Tokyo 108-8639, Japan 3 Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokane-d...