Modelling and application are seen as a highly important topic for maths lessons. But so far the concept “modelling competencies” has not been described in a comprehensive manner. The aim of this paper is to supplement former descriptions of modelling competencies based on empirical data. An empirical study was carried out which aimed at showing the effects of the integration of modelling tasks...

Tetracyclines and macrolide antibiotics have been in use for acne treatment for more than 20 years. Since 1992 increasing resistance to these antibiotics, and especially to erythromycin, is reported with Propionibacterium acnes. Zinc salts have demonstrated their efficacy in inflammatory acne treatment as well as their bacteriostatic activity against Propionibacterium acnes. The objective of ou...

This paper studies the patterns of trade and the incentives to innovate in an unequal global economy. We introduce non-homothetic preferences in a general-equilibrium model of endogenous growth and international trade between two countries, and argue that the effects of market integration on the consequent trade patterns and the incentives to innovate depend on the degree of income inequality a...

S INCE THE INITIAL description of the Ki-l monoclonal antibody (MoAb) in 1982,' there has been an overwhelming flood of information concerning the Hodgkm's disease @)associated molecule CD30. In a diagnostic point of view, the Ki-l antibody enabled in 1985' the identification of a new category of non-Hodgkn's lymphomas designated as Ki"D30 anaplastic large cell lymphoma (ALCL).' The discovery t...

The uterine endometrium plays a critical role in regulating the estrous cycle and the establishment and maintenance of pregnancy in mammalian species. Many studies have investigated the expression and function of genes in the uterine endometrium, but the global expression pattern of genes and relationships among genes differentially expressed in the uterine endometrium during gestation in pigs ...

Data defining the isolated effect of insulin on whole body protein and glucose metabolism in cancer patients are limited. Ten normal volun teers (controls), age 55 ±3 years (mean ±SEM); 8 cancer patients, age 61 ±3years, weight loss 2 ±1% (CANWL); and 8 cancer patients, age 55 ±2 years, weight loss 18 ±2% (CAWL), were studied in the postabsorptive state. Whole body leucine kinetics were d...

The application of ionic processes to the purification of manned space-cabin atmospheres was investigated in anticipation of a need for a radically new atmospheric purification system for some of the presently scheduled space jaurneys. Processes considered are (1) ion-molecule reactions of contaminant mulecules with specific added molecule ions (O0, 0) and (2) clustering of contaminant molecule...

OBJECTIVE To obtain prospective data on feasibility and safety of intra-articular injections of hylan G-F20 in patients with symptomatic hip osteoarthritis (OA). METHODS Fifty-seven patients with primary hip OA, Kellgren-Lawrence grade II-III, aged > or = 40 and walking pain 50-90 mm on a visual analogue scale (VAS) were enrolled in an open-label, multicentre pilot trial. Hylan G-F20 (2 ml) w...

Although many genetic association studies have been carried out, it remains unclear which genes contribute to depression. This may be due to heterogeneity of the DSM-IV category of depression. Specific symptom-dimensions provide a more homogenous phenotype. Furthermore, as effects of individual genes are small, analysis of genetic data at the pathway-level provides more power to detect associat...