conclusions the current study highlights that the high level of resistance to many antibacterial agents and a gradual increase in the degree of per, oxa-10, shv and tem esbls among the majority of imipenem resistant p. aeruginosa isolated from patients with burn infection is an enormous threat in burn centers in iran. results the results showed that the majority of isolates (88%) were multi-dru...

the catalytic highly regio-, diastereo-, and enantioselective synthesis of a small library of spiropyrrolizidineoxindolesvia a four-component 1,3-dipolar cycloaddition reaction of azomethine ylides, derived from isatin, with electron-deficient dipolarophilewas described. the process occurs at room temperature in aqueous ethanol as a green solvent and in the presence of a bidendatebis(imine)–cu(...

introduction industrialization and urbanization of societies have caused many environmental problems. therefore, environmental protection has recently become highly important. water resources are particularly of high risk of pollution from industrial waste disposal to river, surface, and ground water, and also from discharge of water to municipal waste water collection systems. these effluents ...

design of selective cyclooxygenase-2 (cox-2) inhibitors is still a challenging task because of active site similarities between cox isoenzymes. to help with this issue, we tried to generate a 3d-qsar (3 dimensional quantitative structure activity relationship) model that might reflect the essential features of cox-2 active sites. compounds in a series of resveratrol derivatives inhibitors with ...

the activity of one of the metabolizing enzymes of - aminobutyric acid, (gaba), was determined in mouse hypothalamus after peripheral injections of cholecystokinin-8 (cck-8) and caerulein (cln). the activity of this rate-limiting enzyme, l-glutamic acid decarboxylase, (gad), did not change thirty minutes after peripheral injections of either cck-8 or cln in doses of 50g/kg body weight. howeve...

immune responses play critical roles in the leishmaniasis eradication. il-10 is a key regulator of immune responses, and the polymorphisms within its promoter region are associated with alteration in its expression. therefore, this study was designed to examine the correlation between polymorphism at the -1082 position of the il-10 gene and visceral leishmaniasis (vl).the il-10 -1082 polymorphi...

background: the hazardous nature of aflatoxins to human and animals necessitate the establishment of control measures. objectives: the effect of two medicinal plants, satureja khozistanica and satureja macrosiphon, was studied on inhibiting aspergillus flavus growth and reducing aflatoxin b1-content in the liquid medium. methods: essential oils were isolated by hydrodistillation method, using a...

objectives: the aim of this study was to evaluate the effect of gutta percha/ah26 and resilon/realseal se on residual antimicrobial activity of chlorhexidine (chx) in human root dentin and suggest the best filling material when chx is used as final irrigant. materials and methods: one-hundred and forty-four single-rooted human teeth were selected for this study. canals were instrumented to the ...

improvements in the two-step synthesis of 1,1,1,3,3,3-hexafluoro-2- (fluoromehoxy)propane (sevoflurane) that result in the product cost reduction, safety level enhancement and positive environmental impacts are described. this process consists of chloromethylation reaction of 1,1,1,3,3,3-hexafluoro-2-propanol (hfip) followed by a halogen-exchange fluorination. this is the first synthesis of sev...