Approximately 57% of clinical and 33% of poultry isolates examined produced a cytotoxin. Cytotoxic activity was detected in 25 (50%) isolates of Campylobacter of which 12 were isolated from bloody diarrhea and 9 from watery stools. The cytotoxin titers were low, ranging from 2 to 16. The crude filtrates from 50 Campylobacter isolates showed no cytotoxic effect in Vero cells, no fluid accumulati...

Twenty four sera from patients with haemolytic uraemic syndrome or haemorrhagic colitis and healthy controls were examined for antibodies to the lipopolysaccharide (LPS) of Escherichia coli O157. Faecal specimens from these patients were also examined for Vero cytotoxin producing E coli (VTEC) by DNA probes, and for faecal Vero cytotoxin. Eight patients with faecal E coli O157:H7 gave a strong ...

Colorectal cancer is one of the leading causes cancer-related death worldwide. The adenomatous polyposis coli (APC) gene mutated in hereditary colorectal tumors and more than 80% sporadic tumors. APC mutations impair ?-catenin degradation, to its permanent stabilization increased transcription cancer-driving target genes. In colon cancer, impairment degradation leads cytoplasmic accumulation, n...