helicobacter hepaticus was discovered in 1992 as a cause of liver cancer in the a/jcr mouse model. in susceptible mice, infection by h. hepaticus causes chronic gastrointestinal inflammation leading to neoplasia. it can also cause morphological changes in breast-glands leading to neoplasm and adenocarcinoma in mouse models. studies performed on humans have revealed that h. hepaticus may also be...

JUN, Z.J., LEI, Y., SHIMIZU, Y., DOBASHI, K. and MORI, M. High Seroprevalence of Helicobacter pylori in Chronic Bronchitis among Chinese Population. Tohoku J. Exp. Med., 2006, 208 (4), 327-331 ── An increased seroprevalence of Helicobacter pylori (H. pylori), especially high virulent cytotoxin-associated gene-A (CagA) positive strains, has been found in many extragastrointestinal disorders. Mor...

Helicobacter pylori (H. pylori) is causally related to chronic active gastritis, peptic ulcer disease, primary low-grade B-cell gastric lymphoma, and is also a risk factor for gastric cancer. In addition, a high seroprevalence of H. pylori has been found in many extragastrointestinal disorders, including active bronchiectasis and chronic obstructive pulmonary disease (COPD). It appears that H. ...

BACKGROUND Previous studies have reported an association between chronic Helicobacter pylori infection and ischemic heart disease. However, it is not clear whether this association is really due to the virulence of the bacterium or is merely the result of confounding factors (in particular, age and social class). METHODS AND RESULTS We assessed the prevalence of infection by Helicobacter pylo...

BACKGROUND/AIMS Genes associated with the Helicobacter pylori (H. pylori) plasticity region may play a role in the pathogenesis of H. pylori. We compared the genes jhp0940, jhp0947, and jhp0986 in H. pylori isolates from patients with different gastroduodenal diseases and in different age groups. METHODS The H. pylori hyperplasticity region genes jhp0940, jhp0947, and jhp0986 were studied by ...

BACKGROUND: Helicobacter pylori (H. pylori) infection is thought to play an etiologic role in several gastroduodenal diseases including gastric ulcer, duodenal ulcer, gastric MALT lymphoma, and distal gastric cancer. Several studies have suggested that H. pylori which express cytotoxin-associated gene A (CagA) may be more virulent than those that do not, but limited populations have been studie...

background: helicobacter pylori (h. pylori) cytotoxin and its heterogeneity amongst strains has been closely linked to the varying infection-associated clinical outcomes. in order to determine the decisive role of the vacuolating cytotoxin (vaca) gene mosaicism in its corresponding gene expression and phenotype, we aimed to characterize vaca alleles of different h. pylori strains in addition to...

The aim of this study was to evaluate the effect of Helicobacter pylori (H pylori) cytotoxin-associated gene A (CagA) coupled with chronic alcohol ingestion on cytokine profiles.A total of 215 male subjects were divided into the following 4 groups: 130 alcohol H pylori CagA-negative consumers (CagA-) (group A), 50 alcohol H pylori CagA-positive consumers (CagA+) (group B), 24 nonalcohol H pylor...