Cancer gene therapy based on tissue-restricted expression of cytotoxic gene should achieve superior therapeutic index over an unrestricted method. This study compared the therapeutic effects of a highly augmented, prostate-specific gene expression method to a strong constitutive promoter-driven approach. Molecular imaging was coupled to gene therapy to ascertain real-time therapeutic activity. ...

ObjectiveTuberculosis (TB) is a deadly infectious ailment causing mortality and morbidity globally. The study objectives were to investigate the effect possible mechanisms of metformin as adjuvant therapy in management tuberculosis.MethodsTB patients attending HAHC hospital, New Delhi (India) had T2DM (Type-2 diabetes mellitus) comorbidity enrolled. Study participants categorized into non-users...

Mineral Trioxide Aggregate (MTA) is a new material recently approved by the FDA for use in pulpal therapy. MTA has been reported to have superior biocompatibility and sealing ability and is less cytotoxic than other materials currently used in pulpal therapy. This report is a review of MTA's physical and biological properties and the clinical techniques of direct pulp capping, apexification, an...

Twenty years ago, antiestrogen therapy with tamoxifen played only a secondary role in breast cancer care. All hopes to cure metastatic breast cancer were still pinned on either the discovery of new cytotoxic drugs or a dose-dense combination of available cytotoxic drugs with bone marrow transplantation. A similar strategy with combination chemotherapy was employed as an adjuvant for primary bre...

Definition: Tumor lysis syndrome (TLS) is characterized by a group of metabolic derangements including hyperuricemia, hyperkalemia, hyperphosphatemia, hypocalcemia, and uremia.caused by the massive and abrupt release of cellular components into the blood after the rapid lysis of malignant cells. It is observed most frequently in patients with malignancies with high proliferative rate, large tum...

Cancer is a major disease worldwide. Despite progress in cancer therapy, conventional cytotoxic therapies lead to unsatisfactory long-term survival, mainly related to development of drug resistance by tumor cells and toxicity towards normal cells. n-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), can exert anti-neoplastic activity by inducing a...

Twenty years ago, antiestrogen therapy with tamoxifen played only a secondary role in breast cancer care. All hopes to cure metastatic breast cancer were still pinned on either the discovery of new cytotoxic drugs or a dose-dense combination of available cytotoxic drugs with bone marrow transplantation. A similar strategy with combination chemotherapy was employed as an adjuvant for primary bre...

Introduction : Nowadays, using drug delivery is an essential method to improve cancer therapy through decreasing drug toxicity and increasing efficiency of treatment. Silibinin (C25H22O10), a polyphenolic flavonoid which is isolated from the milk thistle plant, has various applications in cancer therapy but it has hydrophobic structure with low water solubility and bioavailability. To increase ...

The palliative efficacy of cytotoxic drugs is routinely assessed using tumor shrinkage (response) rates shown in clinical trials. Although adjuvant drug therapy has a goal distinct from that of palliative therapy (i.e., to prolong survival by inhibiting progression of micrometastatic disease), it is widely assumed that the adjuvant efficacy of a drug will parallel its response rate ("activity")...

Cancer immunotherapy has advanced with the introduction of anti-PD-1 therapy. Anti-PD-1 therapy blocks the inhibitory immune checkpoint receptor PD-1, and allows T cells to regain their cytotoxic potentials in response to cancerous cells. Amongst the cytotoxic lymphocytes other than T cells, natural killer (NK) cells have not been fully explored regarding anti-PD-1 treatment. With this in mind,...