Secondary edematous breast cancer (SEBC), T4b, has a poor prognosis. The aim of this study is to examine the balance in serum levels pro-inflammatory (TNFά, IL-8) and anti-inflammatory (IL-4) cytokines patients with SEBC before special treatment. Materials methods. A total 87 (BC) were examined treatment: 42 T4bN0-3M0 stage 45 BC T3-4N1-3M0 without edema. control group consisted 15 fibroadenoma...

The relationship between the microbiota profile and exposure to stress is not well understood. Therefore, we used a rat model of unpredictable chronic mild (UCMS) investigate this relationship. Depressive-like behaviors were measured in Female Sprague Dawley rats using sucrose preference test Porsolt swim test. Anxiety-like with light–dark box Fecal corticosterone, cecal (composition organic ac...

Limb-girdle muscular dystrophy type 2 (LGMD2B) is a mild form of dysferlinopathy, characterized by limb weakness and wasting. It is an autosomal recessive disease, with currently 140 mutations in the LGMD2B gene identified. Lack of functional dysferlin inhibits muscle fiber regeneration in voluntary muscles, the main pathological finding in LGMD2B patients. However, the immune system has been s...

We analysed the cytokine profile of skin T cells by establishing 11 T-cell lines from adult patients with moderate-to-severe atopic eczema using T-cell growth factors interleukin-2 and interleukin-4. We compared T-cell lines from lesional skin of atopic dermatitis patients with those from non-atopic skin of patients with other skin diseases, observing that T-cell lines of patients with atopic d...

background: preeclampsia is a major cause of mortality and morbidity and is also a leading cause of preterm birth and intrauterine growth retardation. several studies have reported abnormal levels of cytokines in women with preeclampsia. objectives: to detect serum levels of various cytokines in pregnant women with and without preeclampsia in the third trimester of pregnancy. methods: thirty pa...

This review examines recent evidence suggesting a role for the immune system, in particular cytokines, in the pathogenesis of ovarian hyperstimulation syndrome (OHSS). Ovarian tissue is known to contain cells capable of producing a range of immunological mediators and the concentrations of these have been shown to be elevated in serum and ascitic fluid from women with established OHSS. Availabl...

Abstract The objective of this research study is to profile anti-viral and pro-inflammatory cytokines, major histocompatibility complex (MHC) class I & II molecules cell death markers in clinical cases sepsis. Research design included three patient cohorts namely, COVID-19 with sepsis (C19wSepsis, N=17), no (C19NoSepsis, N=17) alone (N=24). Healthy subjects served as controls (N=16). Serum ...

During the last decade, blood purification therapies have been proposed as an effective therapy to control the cytokines dysregulation in systemic inflammatory syndromes. Among them, the treatment with high cut-off membranes is characterized by larger pore size and more effective clearance for middle molecular weight molecules (cytokines). In this paper, we performed a thoughtful review of the ...

Lymphocytic-plasmacytic colitis (LPC) is a common form of inflammatory bowel disease (IBD) affecting the canine large intestine. Cytokines are thought to be involved in the pathogenesis of IBD. However, to date, few studies have investigated cytokine mRNA expression in dogs with LPC. In this study, we investigated mRNA transcription levels of T helper cell cytokines, such as IFN-γ, IL-4, IL-17 ...

Cytokines are intercellular mediators involved in viral control and liver damage being induced by infection with hepatitis C virus (HCV). The complex cytokine network operating during initial infection allows a coordinated, effective development of both innate and adaptive immune responses. However, HCV interferes with cytokines at various levels and escapes immune response by inducing a T-help...