Cyproheptadine (CPH) is a histamine- and serotonin-receptor antagonist, and its effects are observed recently in the modulation of multiple intracellular signals. In this study, we used cortical neurons and HEK-293 cells transfected with Kv2.1 α-subunit to address whether CPH modify neural voltage-gated K(+) channels by a mechanism independent of its serotonergic and histaminergic properties. O...

Rats were trained to discriminate between saline and either 0.3, 1.0, 3.0 or 6.0 mg/kg of diazepam in a two-choice, discrete-trial avoidance procedure. Diazepam, chlordiazepoxide, flurazepam and pentobarbital occasioned dose-related increases in diazepam-appropriate responding in all four training dose groups. Increasing the training dose of diazepam from 0.3 to 1.0 mg/kg resulted in approximat...

teucrium polium is used for treatment of visceral pain in iranian folkloric medicine. in this studyantinociceptive mechanisms of t. polium hydroethanolic extract were examined by acetic acid-inducedwrithing test as a model of visceral pain in male nmri mice. to reveal the antinociceptive mechanisms ofthe extract, we examined the effects of opioidergic, serotonergic, adrenergic and histaminergic...

the methanolic extract of whole plants of solanum nigrum l. was investigated for anti-inflammatory activity on the experimental animal models. the methanolic extract at a concentration of 100 mg.kg-1 and 200 mg.kg-1, p.o. showed the significant dose dependent anti-inflammatory activity in carrageenin and egg white induced hind paw oedema in rats. anti-inflammatory activity of the tested extract...

Abstract The purpose of this study was to explore the inhibitory effect α-methyl-5- hydroxytryptamine (α-methyl-5-HT) on ATP-activated current (IATP) in rat dorsal root ganglion (DRG) neurons. Whole-cell patch clamp experiment performed cultured DRG One minute after treatment with α-methyl-5-HT, ATP (10-4 mol/L) activation neurons inhibited. However, independent caused by α-methyl-5-HT. dose-re...

Objective: Crinum jagus is used in traditional African medicine the treatment of epilepsy, pain and inflammations.
 Methods: Anticonvulsant activity was investigated using picrotoxin (PCT) strychnine (STR) tests experimental paradigm.
 Results: leaf methanol extract (200, 400, 800 mg kg−1) potentiated hexobarbitone-induced sleeping time significantly (p<0.05) shortened duration con...

A 40-year-old woman with bipolar disorder who was taking mirtazapine presented with mydriasis, abnormal diaphoresis, myoclonus and muscle rigidity after taking metocloplamide. Her medical history, which included the use of serotonergic agents, and the presence of symptoms including myoclonus and muscle rigidity were consistent with a diagnosis of serotonin syndrome (SS) according to the Hunter ...