نتایج جستجو برای: cyp450

تعداد نتایج: 731  

Journal: :Prostaglandins & other lipid mediators 2012
Nicholas R Ferreri Shoujin Hao Paulina L Pedraza Bruno Escalante Carlos P Vio

The thick ascending limb of Henle's loop (TAL) is capable of metabolizing arachidonic acid (AA) by cytochrome P450 (CYP450) and cyclooxygenase (COX) pathways and has been identified as a nephron segment that contributes to salt-sensitive hypertension. Previous studies demonstrated a prominent role for CYP450-dependent metabolism of AA to products that inhibited ion transport pathways in the TAL...

2013
Guillermo Gervasini Maria J. Caballero Juan A. Carrillo Julio Benitez

The goal of this study was to assess in human liver microsomes the inhibitory capacity of commonly used antipsychotics on the most prominent CYP450 drug metabolizing enzymes (CYP1A2, CYP2C9, CYP2D6, and CYP3A). Chlorpromazine was the only antipsychotic that inhibited CYP1A2 activity (IC50 = 9.5  μ M), whilst levomepromazine, chlorpromazine, and thioridazine significantly decreased CYP2D6-mediat...

Journal: :Journal of cardiovascular pharmacology 2011
Mona E Aboutabl Beshay N M Zordoky Bruce D Hammock Ayman O S El-Kadi

We recently demonstrated that benzo(a)pyrene (BaP) causes cardiac hypertrophy by altering arachidonic acid metabolism through the induction of the expression of CYP ω-hydroxylases and soluble epoxide hydrolase (sEH) enzymes. The inhibition of CYP ω-hydroxylase enzymes partially reversed the BaP-induced cardiac hypertrophy. Therefore, it is important to examine whether the inhibition of sEH also...

Journal: :Clinical science 2011
Natalie C Ward Kevin D Croft David Blacker Graeme J Hankey Anne Barden Trevor A Mori Ian B Puddey Christopher D Beer

CYP450AAM [arachidonic acid metabolites of the CYP450 (cytochrome P450) enzyme system] have a range of biological functions. CYP450AAM are involved in the pathogenesis of hypertension, renal function and vascular function, yet their role in stroke has not been clarified. We aimed at determining the levels of circulating CYP450 metabolites in patients with acute ischaemic stroke (<96 h) compared...

2017
Benoit Drolet Sylvie Pilote Carolanne Gélinas Alida-Douce Kamaliza Audrey Blais-Boilard Jessica Virgili Dany Patoine Chantale Simard

Arachidonic acid can be metabolized by cytochrome P450 (CYP450) enzymes in a tissue- and cell-specific manner to generate vasoactive products such as epoxyeicosatrienoic acids (EETs-cardioprotective) and hydroxyeicosatetraenoic acids (HETEs-cardiotoxic). Type II diabetes is a well-recognized risk factor for developing cardiovascular disease. A mouse model of Type II diabetes (C57BLKS/J-db/db) w...

Journal: :Free radical research 2001
M L Dubuisson B De Wergifosse P Kremers J Marchand-Brynaert A Trouet J F Rees

Coelenterazine (3,7-dihydro-2-(p-hydroxybenzyl)-6-(p-hydroxyphenyl)-8-benzylimidazolo[1,2-a]pyrazin-3- one) is a substrate for the bioluminescence reaction in many marine animals. Recent work showed that CLZn, its synthetic analogue CLZm, and their common oxidation product coelenteramine (CLM) have strong antioxidative properties in acellular lipid peroxidation systems as well as in rat hepatoc...

Journal: :Genetics and molecular research : GMR 2014
D C Qi B Wu S L Tao J Zhou H X Qian D Wang

Microarray data were collected from bile duct samples from subjects with malignant biliary strictures by endoscopic retrograde cholangiopancreatography to screen for key genes associated with this disease. A predicted interaction network was constructed for these genes to interpret their functions. The gene expression dataset GSE34166 (10 samples: 6 malignant and 4 benign control samples) was d...

2016
Caroline Manicam Julia Staubitz Christoph Brochhausen Franz H. Grus Norbert Pfeiffer Adrian Gericke

Cholinergic regulation of arterial luminal diameter involves intricate network of intercellular communication between the endothelial and smooth muscle cells that is highly dependent on the molecular mediators released by the endothelium. Albeit the well-recognized contribution of nitric oxide (NO) towards vasodilation, the identity of compensatory mechanisms that maintain vasomotor tone when N...

2016
Ni-Ya Zhang Ming Qi Ling Zhao Ming-Kun Zhu Jiao Guo Jie Liu Chang-Qin Gu Shahid Ali Rajput Christopher Steven Krumm De-Sheng Qi Lv-Hui Sun

This study was designed to establish if Curcumin (CM) alleviates Aflatoxin B₁ (AFB₁)-induced hepatotoxic effects and to determine whether alteration of the expression of cytochrome P450 (CYP450) isozymes is involved in the regulation of these effects in chick liver. One-day-old male broilers (n = 120) were divided into four groups and used in a two by two factorial trial in which the main facto...

2009
Anagha Damre S. R. Mallurwar D. Behera

Small intestine plays an important role in the first-pass metabolism of orally ingested xenobiotics as a result of expression of both Phase I and Phase II metabolic enzymes, together with associated transporters. Intestinal microsomes thus can be used to study susceptibility of compounds to metabolism in vitro. The present study was undertaken to have a comparative assessment between different ...

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