AIMS The matrix metalloproteinase (MMP) 2/9, also known as collagenases IV and gelatinases A/B, play a key role in cancer invasion and metastasis. However, the clinical trials of the MMP inhibitors (MMPIs) ended up with disappointing results. In this paper, we synthesized a gelatinase-responsive copolymer (mPEG-PCL) by inserting a gelatinase cleavable peptide (PVGLIG) between mPEG and PCL block...

aim : the aim of this study is to design multi-walled carbon nanotubes (mwcnts) loaded with paclitaxel (ptx) anti-cancer drug and investigate its anti-cancerous efficacy of human gastric cancer. the sidewall surfaces of pristine mwcnts are highly hydrophobic. a major goal in carbon nanotube chemistry has been functionalization for aqueous solubility, and exploiting nano-tubes as macromolecules ...

The direct grafting of amphiphilic macromolecules by sequential n-carboxyanhydride ring-opening polymerisation (NCA ROP) from a therapeutic initiator enables the formation of monodisperse drug-containing micelles. The subsequent enzyme-mediated hydrolysis of the peptide component permits the programmed release of the encapsulated drug molecules, demonstrating a controlled drug delivery platform...

The stimuli-responsive nanocomposites were designed as drug delivery nanocarriers. Thanks to promising properties such as large surface area and easy chemical functionalization, the graphene derivatives can be used for the drug delivery applications. For this purpose, in the current work, the poly(L,D-lactide)-block-poly(N-isopropylacrylamide-rand-acrylic acid) grafted from reduced graphene oxi...

Emulsions are liquid–liquid dispersions with one liquid phase dispersed in the other as small droplets. Nanoemulsions nano-sized emulsions sizes ranging from tens to hundreds of nanometers, and have great potential applications pharmaceutics, foods cosmetics due their attractive properties, such sizes, high surface area per unit volume, improved dispersion active hydrophobic components enhanced...

N-Protected derivatives of 1-amino-cyclo-hexa-neacetic acid (β(3,3)-Ac6c), namely Valeroyl-β(3,3)-Ac6c-OH [2-(1-pentanamidocyclohexyl)acetic acid, C13H23NO3], (I), Fmoc-β(3,3)-Ac6c-OH [2-(1-{[(9H-fluoren-9-yloxy)carbonyl]amino}cyclohexyl)acetic acid, C23H25NO4], (II), and Pyr-β(3,3)-Ac6c-OH {2-[1-(pyrazine-2-amido)cyclohexyl]acetic acid, C13H17N3O3}, (III), were synthesized and their conformati...

Ipidacrine (2,3,5,6,7,8-hexa-hydro-1H-cyclo-penta-[b]quinolin-9-amine) was reacted with 4-methoxy-phenyl isocyanate to give the title compound, C(28)H(30)N(4)O(4). An intra-molecular N-H⋯O hydrogen bond results in an essentially planar [r.m.s. deviation from the mean plane is 0.126 (1) Å] conformation for the biuret unit. The central ring of the quinoline unit is twisted by 78.2 (1)° with respe...

In the centrosymmetric title compound, C26H16N4O4 {systematic name: 6,13-bis-[(pyridin-4-yl)meth-yl]-6,13-di-aza-tetra-cyclo-[6.6.2.0(4,16)0(11,15)]hexa-deca-1,3,8,10,15-pantaene-5,7,12,14-tetrone}, the central ring system is essentially planar [maximum deviation = 0.0234 (8) Å] and approximately perpendicular to the terminal pyridine ring [dihedral angle = 84.38 (3)°]. The mol-ecules displays ...

The title compound, C(29)H(19)F(6)NOS(2), is a new unsymmetrical photochromic diarylethene derivative with different meta-phenyl substituents. The distance between the two reactive (i.e. can be irradiated to form a new chemical bond) C atoms is 3.501 (4) Å; the dihedral angles between the mean plane of the main central cyclo-pentene ring and the thio-phene rings are 47.7 (5) and 45.1 (2)°, and ...

To overcome the problems associated with conventional liposomes in transdermal drug delivery like limited penetration ability and poor stability, in this article we report a new generation of cell penetrating peptide polyarginine containing nano-liposomes conjugated with carbon dots. The newly synthesized, cost-effective liposomic precursors were used for the fabrication of liposomes. The resul...