Hypothetical proteins comprise roughly half of the predicted gene complement of Toxoplasma gondii and Plasmodium falciparum and represent the largest class of uniquely functioning proteins in these parasites. Following the idea that functional relationships can be informed by the timing of gene expression, we devised a strategy to identify the core set of apicomplexan cell division cycling gene...

BACKGROUND Iron-deficiency anemia is the most common type of nutritional disorder. New strategies for the treatment of anemia are very important for its reduction. The aim of this study was to assess the efficacy and feasibility of cyclical iron supplementation as a strategy to reduce the prevalence of anemia among preschoolers. METHODS A randomized controlled trial was performed in the entir...

We review the basic characteristics of four periodic hematological disorders (periodic auto-immune hemolytic anemia, cyclical thrombocytopenia, cyclical neutropenia and periodic chronic myelogenous leukemia) and examine the role that mathematical modeling and numerical simulations have played in our understanding of the origin of these diseases and in the regulation of hematopoiesis.

We have recently introduced an incremental learning algorithm, Learn.NSE, for Non-Stationary Environments, where the data distribution changes over time due to concept drift. Learn.NSE is an ensemble of classifiers approach, training a new classifier on each consecutive batch of data that become available, and combining them through an age-adjusted dynamic error based weighted majority voting. ...

In this work, we analyzed and compared two patterns of movement according to a rhythmic signal (dancing vs. cyclical rhythmic movements) to create a more natural virtual dancing partner with haptic feedback. We observed linear movements to reduce the analysis complexity and highlight the critical factors that can be generalized to unconstrained movements. Results indicate that dancing movements...

Recent high-profile corporate scandals are reminiscent of the corporate raider scandals of the 1980s, suggesting that ethical scandals may occur in waves. This article provides a framework for analysis of this question by suggesting that ethical attitudes may be cyclical about long-term secular trends. We provide some empirical evidence from previously published work for the existence of cycles...

K advertising, or sponsored search, is one of the most successful advertising models on the Internet. One distinctive feature of keyword auctions is that they enable advertisers to adjust their bids and rankings dynamically, and the payoffs are realized in real time. We capture this unique feature with a dynamic model and identify an equilibrium bidding strategy. We find that under certain cond...

In this paper, we investigate the long run dynamics of the intraday range of the GBP/USD, JPY/USD and CHF/USD exchange rates. We use a non-parametric filter to extract the low frequency component of the intraday range, and model the cyclical deviation of the range from the long run trend as a stationary autoregressive process. We find that the long run trend is time-varying but highly persisten...

Our analysis based on the National Longitudinal Survey of Youth for the 1978–1999 period concludes that men’s greater representation in cyclical occupational groups, such as craftsmen, operatives, and laborers, more than accounts for the gap between men and women in the cyclicality of real wages. D 2005 Elsevier B.V. All rights reserved.