Bitter substances are a structurally diverse group of compounds that appear to act via several transduction mechanisms. The bitter-tasting denatonium ion has been proposed to act via two different G-protein-regulated pathways, one involving inositol 1,4, 5-trisphosphate and raised intracellular calcium levels, the other involving phosphodiesterase and membrane depolarization via a cyclic nucleo...

Numerical modeling was carried out to investigate the responses of suction bucket foundations under vertical cyclic loading. Numerical results were compared with centrifuge experiment results. Before the capacity of the model suction bucket to resist cyclic loading could be investigated, the static pullout capacities had to be determined. The buckets with different aspect ratio are investigated...

‎‎A natural generalization of two dimensional cyclic code ($T{TDC}$) is two dimensional skew cyclic code‎. ‎It is well-known that there is a correspondence between two dimensional skew cyclic codes and left ideals of the quotient ring $R_n:=F[x,y;rho,theta]/_l$‎. ‎In this paper we characterize the left ideals of the ring $R_n$ with two methods and find the generator matrix for two dimensional s...

Bordetella pertussis, the causative agent of whooping cough, possesses an array of virulence factors, including adenylate cyclase toxin (ACT), relevant in the establishment of infection. Here we better define the impact of cyclic AMP (cAMP) intoxication due to the action of ACT on dendritic cell (DC)-driven immune response, by infecting monocyte-derived DC (MDDC) with an ACT-deficient B. pertus...

A novel MnO2 nanorods modified screen-printed electrode was fabricated and used as a voltammetric sensor for Sudan determination. were characterized using Field emission-scanning electron microscopy (FE-SEM). Electrochemical measurements performed cyclic voltammetry (CV), linear sweep (LSV), differential pulse (DPV), chronoammperometry (CA). The on the surface act an excellent catalyst oxidatio...

We have explored the possibilities that cell volume is regulated by the status of microtubule assembly and cyclic AMP metabolism and may be coordinated with shape change. Treatment of J774.2 mouse macrophages with colchicine caused rapid microtubule disassembly and was associated with a striking increase (from 15-20 to more than 90 percent) in the proportion of cells with a large protuberance a...

in a large scale cyclic storage system ,as the number of rule parameters and/or number of operating period increase, general purpose gradient-based nlp solvers and/or genetic algorithms may loose their merits in finding optimally feasible solution to the problem. in these cases hybrid ga which decomposes the main problem into two manageable sub-problems with an iterative scheme between ga and l...

Cyclic dimers and trimers of tetra-substituted benzenes, ((HOOC)2-C6H2-(NHI)2), are selected as convenient model systems for investigating NI…O=C halogen bond strength cooperativity. The four substituents in benzene chosen so that two them act acceptors (COOH) donors (NHI), shown the graphical abstract below. potential metal ion binding by each halogen-bonded aggregates is also investigated usi...