T he discovery of the cyclic nucleotides 3',5'cyclic monophosphate (cAMP, Prod. No. A 9501, A 4137) and guanosine 3',5'-cyclic monophosphate (cGMP, Prod. No. G 7504, G 6129) led to the first formulation of the second messenger concept. These cyclic nucleotides are now known to be ubiquitous intracellular second messengers that mediate the response of cells to a variety of extracellular stimuli ...

Thymus is regarded as one of the medicinal species, which according to obtained chromatograms of floral water of Thymus; one of the main components is thymol as strong antioxidant. In this study the appropriate and physically powerful correlation was found between the anti-radical and oxidation potentials. The antioxidant activity of the Thymus was measured by using square wave and cyclic volta...

The compensatory growth, proximate composition and amino acid contents changes of young yellow catfish (Pelteobagrus fulvidraco R.) (1.63-1.69 g) had been investigated using a 45-day cyclic feed deprivation and re-feeding experiment. The control group (S0) was fed daily with live tubificid worms (Limnodrilus hoffmeisteri), while the S1/4, S1/2, and S1/1 groups cyclically experienced one-day of ...

A positive integer n is called cyclic if there is a unique group of order n, which is necessarily cyclic. Using a characterisation of the cyclic integers as those n satisfying gcd(n, φ(n)) = 1, P. Erdős (1947) proved that the number of cyclic integers n ≤ x is asymptotic to z(x) = e−γ x log log log x , as x→∞, where γ is Euler’s constant. An ordered pair of integers (m,n) is called singular if ...

BACKGROUND AND PURPOSE The sphingosine 1-phosphate receptor subtype 1 (S1P1R) is modulated by phosphorylated FTY720 (pFTY720), which causes S1P1R internalization preventing lymphocyte migration thus limiting autoimmune response. Studies indicate that internalized S1P1Rs continue to signal, maintaining an inhibition of cAMP, thus raising question whether the effects of pFTY720 are due to transie...

Cyclic sulfate is the precursor compound that can adapt well to binding sites of docked proteins SARS-CoV-2. showed very strong molecular interactions for 6lu7, 6zb5, and 6vww SARS-CoV-2, with energies -7.33, -7.29, -7.29 kcal mol-1, respectively. Besides, acetate -7.45 mol-1 6lu7 protein Therefore, according our results, cyclic should be investigated as promising drug candidates treatment COVI...