نتایج جستجو برای: cxcl10

تعداد نتایج: 2168  

Journal: :Journal of virology 2004
Matthew J Trifilo Cynthia Montalto-Morrison Linda N Stiles Kelley R Hurst Jenny L Hardison Jerry E Manning Paul S Masters Thomas E Lane

How chemokines shape the immune response to viral infection of the central nervous system (CNS) has largely been considered within the context of recruitment and activation of antigen-specific lymphocytes. However, chemokines are expressed early following viral infection, suggesting an important role in coordinating innate immune responses. Herein, we evaluated the contributions of CXC chemokin...

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Journal: :Diabetes 2015
Stanley Lasch Peter Müller Monika Bayer Josef M Pfeilschifter Andrew D Luster Edith Hintermann Urs Christen

Anti-CD3 therapy of type 1 diabetes results in a temporary halt of its pathogenesis but does not constitute a permanent cure. One problem is the reinfiltration of islets of Langerhans with regenerated, autoaggressive lymphocytes. We aimed at blocking such a reentry by neutralizing the key chemokine CXCL10. Combination therapy of diabetic RIP-LCMV and NOD mice with anti-CD3 and anti-CXCL10 antib...

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Journal: :Blood 2016

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Journal: :Pharmacological reports : PR 2006
Grazyna Michałowska-Wender Jacek Losy Adam Szczuciński Justyna Biernacka-Łukanty Mieczysław Wender

In order to elucidate the mechanism of intravenous methylprednisolone (IVMP) therapy of relapses in multiple sclerosis (MS) patients, we have undertaken a study on the expression of the chemokines: soluble platelet endothelial cell adhesion molecule (sPECAM-1) and interferon gamma-inducible protein (CXCL10), before and after treatment. As more becomes known about the mechanism of methylpredniso...

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2017
Guang Li Xian Li Meng Yang Lvzi Xu Shixiong Deng Longke Ran

Microarray data is used to screen the genes of oral squamous cell carcinoma (OSCC). Microarray data of OSCC and normal tissues were downloaded from GEO database and analyzed with Benjamini-Hochberg (BH) method. Differentially expressed genes (DEGs) were then uploaded on DAVID database to process enrichment analysis. Target genes were finally chosen for verification experiment in vitro and in vi...

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Journal: :The Journal of Experimental Medicine 2003
Laura Lasagni Michela Francalanci Francesco Annunziato Elena Lazzeri Stefano Giannini Lorenzo Cosmi Costanza Sagrinati Benedetta Mazzinghi Claudio Orlando Enrico Maggi Fabio Marra Sergio Romagnani Mario Serio Paola Romagnani

The chemokines CXCL9/Mig, CXCL10/IP-10, and CXCL11/I-TAC regulate lymphocyte chemotaxis, mediate vascular pericyte proliferation, and act as angiostatic agents, thus inhibiting tumor growth. These multiple activities are apparently mediated by a unique G protein-coupled receptor, termed CXCR3. The chemokine CXCL4/PF4 shares several activities with CXCL9, CXCL10, and CXCL11, including a powerful...

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Journal: :Journal of immunology 2002
Lidia Michalec Barun K Choudhury Edward Postlethwait James S Wild Rafeul Alam Michael Lett-Brown Sanjiv Sur

Oxidative stress from ozone (O(3)) exposure augments airway neutrophil recruitment and chemokine production. We and others have shown that severe and sudden asthma is associated with airway neutrophilia, and that O(3) oxidative stress is likely to augment neutrophilic airway inflammation in severe asthma. However, very little is known about chemokines that orchestrate oxidative stress-induced n...

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2017
Claudia Mascia Serena Vita Paola Zuccalà Raffaella Marocco Tiziana Tieghi Stefano Savinelli Raffaella Rossi Marco Iannetta Irene Pozzetto Caterina Furlan Fabio Mengoni Claudio Maria Mastroianni Vincenzo Vullo Miriam Lichtner

BACKGROUND AND AIMS Increased levels of chemokine interferon-gamma (IFN-γ)-inducible protein-10 (CXCL10), soluble CD163 (sCD163) and soluble CD14 (sCD14) have been reported in HCV infection. The aim of this study was to compare, sCD163 and sCD14 levels in HCV-infected patients undergoing direct acting antiviral (DAA)-containing regimens with or without interferon (IFN). METHODS sCD163, sCD14 ...

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Journal: :Journal of the American Society of Nephrology : JASN 2006
Ulf Panzer Oliver M Steinmetz Rüdiger R Reinking Tobias N Meyer Susanne Fehr André Schneider Gunther Zahner Gunter Wolf Udo Helmchen Patrick Schaerli Rolf A K Stahl Friedrich Thaiss

The recruitment of inflammatory cells into renal tissue, mainly T cells and monocytes, is a typical feature of various renal diseases such as glomerulonephritis, thrombotic angiopathies, allograft rejection, and vasculitis. T cells predominantly infiltrate the tubulointerstitium, whereas monocytes are present in the tubulointerstitial and glomerular compartment. Because chemokines play a pivota...

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Journal: :Proceedings of the National Academy of Sciences of the United States of America 2011
Silvia Stojanov Sivia Lapidus Puja Chitkara Henry Feder Juan C Salazar Thomas A Fleisher Margaret R Brown Kathryn M Edwards Michael M Ward Robert A Colbert Hong-Wei Sun Geryl M Wood Beverly K Barham Anne Jones Ivona Aksentijevich Raphaela Goldbach-Mansky Balu Athreya Karyl S Barron Daniel L Kastner

The syndrome of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) is the most common periodic fever disease in children. However, the pathogenesis is unknown. Using a systems biology approach we analyzed blood samples from PFAPA patients whose genetic testing excluded hereditary periodic fevers (HPFs), and from healthy children and pediatric HPF patients. Gene expr...

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    • "; pgn_html+=pgn_li; } document.getElementById("pgn-ul").innerHTML=pgn_html var pgn_links = document.querySelectorAll('.mypgn'); pgn_links.forEach(function(pgn_link) { pgn_link.addEventListener('click', paginate) }) } function post_and_fetch(data,url) { showLoading() xhr = new XMLHttpRequest(); xhr.open('POST', url, true); xhr.setRequestHeader('Content-Type', 'application/json; charset=UTF-8'); xhr.onreadystatechange = function() { if (xhr.readyState === 4 && xhr.status === 200) { var resp = xhr.responseText; resp_json=JSON.parse(resp) resp_place = document.getElementById("search_result_div") resp_place.innerHTML = resp_json['results'] search_meta = resp_json['meta'] update_search_meta(search_meta) update_pagination() hideLoading() } }; xhr.send(JSON.stringify(data)); } function unfilter() { url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":"unfilter", "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } function deactivate_all_bars(){ var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(bar) { bar.dataset.active = false bar.style = "stroke:#71a3c5;" }) } year_chart.on("created", function() { var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(check) { check.addEventListener('click', checkIndex); }) }); function checkIndex(event) { var yrchart = document.querySelectorAll('.ct-bar'); var year_bar = event.target if (year_bar.dataset.active == "true") { unfilter_res = unfilter() year_bar.dataset.active = false year_bar.style = "stroke:#1d2b3699;" } else { deactivate_all_bars() year_bar.dataset.active = true year_bar.style = "stroke:#e56f6f;" filter_year = chart_data['labels'][Array.from(yrchart).indexOf(year_bar)] url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":filter_year, "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } } function showLoading() { document.getElementById("loading").style.display = "block"; setTimeout(hideLoading, 10000); // 10 seconds } function hideLoading() { document.getElementById("loading").style.display = "none"; } -->