Patients with chronic kidney disease (CKD) experience serious adverse cardiovascular (CV) consequences. Cardiovascular disease is the leading cause of morbidity and mortality in patients with CKD, being secondary not only to an increased prevalence of traditional CV risk factors, but also to the presence of a wide array of nontraditional risk factors unique to patients with CKD. Pathogenesis in...

BACKGROUND Patients with rheumatoid arthritis (RA) have double the risk of cardiovascular (CV) disease, largely independently of traditional CV risk factors. Renal dysfunction is associated with CV morbidity and mortality in the general population, but data on this association in RA are lacking. OBJECTIVE To investigate the association between renal function and CV events in RA. METHODS The...

BACKGROUND Statins are effective for primary prevention of cardiovascular (CV) disease, the leading cause of death in the world. Multinational guidelines emphasize CV risk as an important factor for optimal statin prescribing. However, it's not clear how primary care providers (PCPs) use this information. The objective of this study was to determine how primary care providers use information ab...

Cerebrovascular (CV) dysfunction is emerging as a critical component of Alzheimer's disease (AD), including altered CV coverage. Angiogenic growth factors (AGFs) are key for controlling CV coverage, especially during disease pathology. Therefore, evaluating the effects of AGFs in vivo can provide important information on the role of CV coverage in AD. We recently demonstrated that epidermal gro...

OBJECTIVE To compare the incidence of cardiovascular (CV) events in persons with rheumatoid arthritis (RA) with that in people from the general population, adjusting for traditional CV risk factors. METHODS Two hundred thirty-six consecutive patients with RA were assessed for the 1-year occurrence of 1) CV-related hospitalizations, including myocardial infarction, stroke or other arterial occ...

We prove that for k ≥ 5 there does not exist a continuous map ∂CV (Fk) → PCurr(Fk) that is either Out(Fk)-equivariant or Out(Fk)-anti-equivariant. Here ∂CV (Fk) is the “length-function” boundary of Culler-Vogtmann’s Outer space CV (Fk), and PCurr(Fk) is the space of projectivized geodesic currents for Fk. We also prove that, if k ≥ 3, for the action of Out(Fk) on PCurr(Fk) and for the diagonal ...

In order to determine the ability of single-breath nitrogen closing volume (CV) to detect early airway obstruction, the CV was measured in patients with either minimal obstruction of spirometry or with increased residual volume (RV). A total of 39 subjects was included in this study. The mean CV was largest in patients who had reduced maximum mid-expiratory flow rates (MMF). There was no differ...

The cyanobacterial protein cyanovirin-N (CV-N) potently inactivates diverse strains of HIV-1 and other lentiviruses due to irreversible binding of CV-N to the viral envelope glycoprotein gp120. In this study, we show that recombinant CV-N effectively blocks HIV-1(Ba-L) infection of human ectocervical explants. Furthermore, we demonstrate the in vivo efficacy of CV-N gel in a vaginal challenge m...

To serve seamless mapping, airborne LiDAR data are usually collected with multiple parallel strips with one or two cross strip(s). Nevertheless, the overlapping regions of LiDAR data strips are usually found with unbalanced intensity values, resulting in the appearance of stripping noise. Despite that physical intensity correction methods are recently proposed, some of the system and environmen...

OBJECTIVE To determine the influence of ischaemic cardiovascular (CV) risk on prescription of non-steroidal anti-inflammatory drugs (NSAIDs) by general practitioners (GPs) in patients with musculoskeletal complaints. DESIGN Cohort study. SETTING A healthcare database containing the electronic GP medical records of over one million patients throughout the Netherlands. PATIENTS A total of 4...