telomerase activation is one of the main pathways to immortalize cancer cells. in many kinds of cancer cells, this special reverse transcriptase stabilizes and elongates telomeres and prevents telomere erosion that naturally occurs in every cell division. esophageal cancer is the fifth most frequent cause of cancer death worldwide, and is highly associated with alcohol, smoking, cultural habits...

introduction: squamous cell carcinoma of the oral cavity is one of the most important and common types of head and neck malignancy, with an estimated rate of 4% among all human malignancies. the aim of this study was to determine the association between expression of matrix metalloproteinase 2 and 9 and the clinicopathological features of oral squamous cell carcinoma (oscc).   materials and met...

background cervical cancer is the leading cause of death from cancer in under-developed countries. human papilloma virus (hpv) 16 and 18 are the most prevalent types associated with carcinogenesis in the cervix. conventional polymerase chain reaction (pcr), type-specific and consensus primer-based pcr followed by sequencing, restriction fragment length polymorphism (rflp) or hybridization by sp...

background: new blood vessels formation is a critical step in tumor progression. vascular density affects the clinical outcome and prognosis of malignant tumors. the aim of this study was to investigate the relation between the vascular endothelial growth factor (vegf) expression and vascular density with the clinical and histopathologic features in oral squamous cell carcinoma (oscc).   method...

human papillomavirus (hpv) has also been suggested as an etiology of esophageal squamous cell carcinoma (scc). the aim of this study was to investigate the prevalence of hpv infection in esophageal sccs in our region with strict contamination control to prevent false positive results. thirty cases of esophageal squamous cell carcinomas were chosen by simple random selection in a period of two y...

oral lichen planus (olp) is classified as a potential malignant disorder, and epidermal growth factor (egf) may play a key role in cancer development. the aim of this study was to compare serum and saliva egf among patients with olp and oral squamous cell carcinoma (oscc). a cross-sectional study was performed on 27 patients with olp (10 reticular and 17 atrophic-erosive forms), 27 patients wit...