Various terms have been suggested to describe non-ossifying fibroma including fibrous cortical defect, cortical desmoid, metaphyseal fibrous defect and non-osteogenic fibroma. Regardless of the term used, they probable all refer to abnormal osteoclastogenesis at the metaphyseal region. Non-ossifying fibroma is a benign fibrogenic tumor primarily affecting children and adolescents. It is the mos...

Within the confusing ray of fibro-osseous lesions, the so called juvenile ossifying Fibroma (JAOF) is perhaps the most enigmatic. Pathologists considering such a diagnosis are faced with a plethora of subjective and arbitrary criteria and will find little consolidation in the literature. Occupying a subset within the spectrum of ossifying Fibroma. JAOF is considered by many to be a unique lesio...

In the experiments presented, Virus myxomatosum was observed to produce only a localized fibromatous or myxomatous orchitis when injected into the testicles of cottontail rabbits. This type of disease was quite unlike the acute fatal illness which the virus caused in domestic rabbits. 10 serial passages of Virus myxomatosum through cottontail rabbits, covering a total elapsed time of 140 days, ...

Ghost cell differentiation within an ameloblastic fibroma is extremely rare. The ghost cells found in an ameloblastic fibroma in previously reported cases were all associated with a typical calcifying odontogenic cyst. Here, we report a case of an ameloblastic fibroma with focal ghost cells and calcifications in some neoplastic epithelial islands, but without other histologic manifestations con...

Desmoplastic fibroma of bone is a rare myofibroblastic tumor, locally aggressive, benign lesion that histologically resembles a desmoid tumor of the soft-tissue. It was initially described in 1958 by Jaffe, who separated it as a distinct entity from other intraosseous fibrous tumors. This tumor constitutes <1% of bone tumors and about 0.3% of all benign osseous tumors and it usually involves th...

Fibroma is one of the most common soft tissue benign tumors of the oral cavity. These masses represent hyperplasias instead of true neoplasm, which develop due to irritation to the mucosal tissue resulting in proliferation of the cells. Although so common in the oral cavity, its occurrence on the palate is rare, mainly due to fewer chances of trauma. Here, we report a case of palatal fibroma in...

Cemento-ossifying fibroma is a benign fibroosseous lesion that contains fibrous tissue and calcified tissue resembling bone, cementum or both. It is frequently seen in the mandibula and maxilla, but it may rarely affect the ethmoid sinus. In this report, we presented computed tomography findings of an ossifying fibroma of the ethmoid sinus associated with exophthalmos. A 25-year-old woman prese...

Isolated soft tissue enlargements seen in the oral cavity are generally a reactive hyperplasia and rarely neoplastic. Irritation fibroma is a benign tumor of fibrous connective tissue that can be considered a reactionary connective tissue hyperplasia in response to trauma and irritation. It is a gingival lesion of reactive nature with unknown etiology. As the lesion occurs due to continuous tra...

The giant cell fibroma is a localized reactive proliferation of fibrous tissue, much like the irritation fibroma. It usually small, may have be sessile/peduncalated. It is painless, often has lobules/ nodules on its surface. It contains cells with large, stellate shaped fibroblasts, near the surface of the fibrous mass, beneath the overlying epithelium. A female patient aged 45 years presented ...

Melanonychia corresponds to color patterns in the nail plate, ranging from brown to black. It is a diagnostic challenge due to the fact it has several differential diagnoses, including benign and malignant entities. There are no reports of pigmented fibroma of the nail matrix causing striata (or longitudinal) melanonychia. In light of this fact, the authors report a case of melanonychia striata...