Lung cancer mortality was examined in a cohort of 4393 men employed at a zinc-lead-cadmium smelter. There was an excess of lung cancer (overall SMR = 124.5, 95% confidence interval 107-144) which was particularly evident for those employed for more than 20 years. A statistically significant trend in SMRs with increasing duration of employment was apparent. Quantitative estimates of exposure to ...

OBJECTIVE To determine whether exposure to allopurinol is associated with an increased risk of cataract extraction in elderly patients. METHODS We conducted a case-control study using data from the Quebec universal health insurance program for all elderly patients. The 3677 cases were patients with a cataract extraction between 1992 and 1994. The 21,868 controls were randomly selected among p...

The aim of the present meta-analysis was to identify whether there was a relationship between mobile phone use and risk of brain tumor. A comprehensive search strategy was developed, and studies were eliminated in a stepwise manner, based on the inclusion criteria. The current meta-analysis collected data from the 24 eligible studies to investigate the relationship between mobile phone use and ...

STUDY OBJECTIVE This industry-wide longitudinal study examines chest radiographic changes of workers manufacturing refractory ceramic fibers (RCF). DESIGN Chest radiographs were obtained every 3 years and were interpreted using the 1980 International Labour Organization classification for pneumoconiosis. Three exposure metrics were calculated: duration and latency in a production job, and cum...

In order to elucidate the photophysical mechanisms of cellular phototoxicity sensitized by doxycycline, MGH-U1 human bladder carcinoma cells in vitro were treated with 20.7 microM doxycycline and irradiated with either a pulsed (lambda = 355 nm, pulse duration = 24 ps) or a continuous wave (lambda = 351 nm) laser. Cumulative radiant exposure and irradiance were systematically varied in experime...

A single session of repetitive transcranial magnetic stimulation (rTMS) can induce behavioural effects that outlast the duration of the stimulation train itself (off-line effects). Series of rTMS sessions on consecutive days are being used for therapeutic applications in a variety of disorders and are assumed to lead to the build-up of cumulative effects. However, no studies have carefully asse...

Total and cause specific mortality and cancer morbidity were studied among 1929 asbestos cement workers with an estimated median cumulative exposure of 2.3 fibre (f)-years/ml (median intensity 1.2 f/ml, predominantly chrysotile). A local reference cohort of 1233 industrial workers and non-case referents from the exposed cohort were used for comparisons. The risk for pleural mesothelioma was sig...

Although military service, and particularly absence due to deployment, has been linked to risk for depression and anxiety among some spouses and children of active duty service members, there is limited research to explain the heterogeneity in family members' reactions to military service stressors. The current investigation introduces the Timeline Followback Military Family Interview (TFMFI) a...

Objectives: To explore two different approaches to calculate average exposure in occupational cohorts using a large occupational cohort as an example. The data for occupational cohort exposed to acrylonitrile was collected and analyzed previously by NCI; outcome was lung cancer. Methods: Both approaches use cumulative exposure as the numerator. As the denominator, one uses the duration of expos...