background: nowadays, highly specific aptamers generated by cell selex technology (systematic evolution of ligands by exponential enrichment) are being applied for early detection of cancer cells. prostate specific membrane antigen (psma), over expressed in prostate cancer, is a highly specific marker and therefore can be used for diagnosis of the prostate cancer cells. the aim of the present s...

Cancer is among the leading causes of death and an important barrier to improving life expectancy globally. Prostate cancer second most common in men worldwide. The detection biomarkers body fluids key topic for diagnosis prognosis prostate cancer. Despite advances methods, therapeutic agents new biomarkers, remains a serious challenge. Prostate-specific antigen (PSA) widely recognized as bioma...

In the recent years, interstitial brachytherapy implantation has become the treatment of choice for early stage prostate cancer patients. Treatment of prostate cancer with radiation is traced back to 1909. Originally this treatment modality was very crude and could not gain much popularity till 1982. Advancements in radioactive source designs, introduction of new low energy radioactive sources,...

introduction accurate estimation of the skin-absorbed dose in external radiation therapy is essential to estimating the probability of secondary carcinogenesis induction materials and methods electron contamination in prostate radiotherapy was investigated using the monte carlo (mc) code calculation. in addition, field size dependence of the skin dose was assessed. excess cancer risk induced by...

objective: prostate cancer is the second most common cancer worldwide. chemotherapeutic agents have been shown to have adverse side-effects, and natural compounds have been recommended for cancer treatment, nowadays. crab shell has been shown to have cancer preventative and suppressive effects in vivo and in vitro. the aim of present study was to investigate the effect of crab shell extract on ...

a 65 year-old overweight man with a history of prostate cancer was referred to our nuclear medicine department for bone scanning. anterior projection images showed two small foci of increased radiotracer uptake corresponding to the anterior arcs of the right and left sixth ribs, which were interpreted as suspicious for metastatic involvement. eight months later the patient was referred for foll...

the previous large retrospective studies demonstrated that treatment with statins reduces both the incidence of prostate cancer by 50% and serum prostate specific antigen (psa) level up to 40%. however the main problem in those studies was the absence of control groups of men with hypercholesterolemia without statin treatment. we performed a small prospective controlled clinical trial to assess...

objective: prostate cancer is one of the most common cancer in the developed countries. most of cancer deaths are due to development of metastasis. hence, prevention of metastasis is critical. silibinin is a flavonoid component that inhibits cell proliferation and causes cell death of human prostate cancer. in this study, the expression of cd82 gene in pc-3 cells treated with escalating concent...

objective(s): we performed a phase iia clinical trial of trans-1-amino-3-18ffluoro-cyclobutane carboxylic acid (anti-18f-facbc), a synthetic amino acid analog for pet, in patients with metastatic prostate cancer. methods: the study subjects consisted of 10 untreated prostate cancer patients having lymph node and/or bone metastasis. five patients underwent whole-body pet 5 and 30 min after intra...