Background: The last decades have witnessed remarkable progress in the field of endoscopic skull base surgery. The nose has become an established route for addressing different skull base lesions. The reconstruction after resection is a critical step for optimum surgical outcome. Objective: Evaluation of the difference in the clinical outcomes between the use of vascularized flaps and free graf...

We compared the frequency of rhinorrhea between 34 Parkinson's disease (PD) subjects and 15 normal controls (NC) and explored relationships between rhinorrhea and clinical functions, and degree of nigrostriatal dopaminergic denervation using [(11)C]dihydrotetrabenazine (DTBZ) brain positron emission tomography imaging. Sixty-eight percent (23 of 34) of PD subjects reported rhinorrhea of any cau...

In an attempt to improve the diagnosis and to assess the intensity of intermittent cerebrospinal fluid rhinorrhea, indium-111 uptake by nasal pledgets during prolonged cisternography using 111In-DTPA was determined. In 12 patients having suspected cerebrospinal fluid rhinorrhea, cisternograms with calculation of counts/pixel in regions of interest were obtained, blood samples drawn, and nasal p...

frontal sinus fractures are of surgical importance because of the microbial flora covering the frontal air sinus and it's proximity with the duramater and brain. there is an increased risk of meningitis when fracture of the posterior wall of the frontal sinus is associated with a dural tear. in this condition, communication occurs between the contaminated space of the air sinus and the int...

Background: Patients with skull base cerebrospinal fluid (CSF) leaks present headaches, in the ear(s), and/or rhinorrhea, which are vague symptoms. Beta-2-transferrin protein assays gold standard for identifying CSF leaks, but adequate samples cannot always be collected, and results give no specific localizing information. Medical imaging, including Computed Tomography (CT), Magnetic Resonance ...

BACKGROUND Intrasphenoidal encephalocele (ISE) is a rare clinical entity. The incidence of congenital encephalocele is very low. Accurate diagnosis and surgical approach is of critical value. CASE REPORTS We present a case of intrasphenoidal encephalocele in a 40-year-old man. He complained of cerebrospinal fluid (CSF) rhinorrhea and recurrent meningitis. In images of computed tomography (CT)...

OBJECTIVE To compare the efficacy of amoxicillin vs placebo in patients with an acute upper respiratory tract infection and purulent rhinorrhea. STUDY DESIGN Double-blind randomized placebo-controlled trial. POPULATION The 416 patients included from 69 family practices were 12 years or older, presenting with acute upper respiratory complaints, and having a history of purulent rhinorrhea and...

The aim of the present report was to present the patient with an anterior cranial base fracture who developed post-traumatic cerebrospinal fluid rhinorrhea, which recovered after onset of meningitis complication. A 26-year-old male patient who had a traffic accident one week ago was sent to our clinic because of his rhinorrhea persisting for 4 days. On cranial computed tomography, fracture of t...

Objectives To review the safety and efficacy of surgical management for spontaneous cerebrospinal fluid (CSF) leaks of the anterior and lateral skull base. Data Sources A systematic review of English articles using MEDLINE. Review Methods Search terms included spontaneous, CSF, cerebrospinal fluid, endoscopic, middle fossa, transmastoid, leak, rhinorrhea. Independent extraction of articles ...