نتایج جستجو برای: crystallography
تعداد نتایج: 11029 فیلتر نتایج به سال:
Fragment-based drug discovery (FBDD) concerns the screening of low-molecular weight compounds against macromolecular targets of clinical relevance. These compounds act as starting points for the development of drugs. FBDD has evolved and grown in popularity over the past 15 years. In this paper, the rationale and technology behind the use of X-ray crystallography in fragment based screening (FB...
Electron crystallography is especially useful for studying the structure and function of membrane proteins - key molecules with important functions in neural and other cells. Electron crystallography is now an established technique for analyzing the structures of membrane proteins in lipid bilayers that closely simulate their natural biological environment. Utilizing cryo-electron microscopes w...
The use of protein X-ray crystallography for structure-based design of small-molecule drugs is well-documented and includes several notable success stories. However, it is less well-known that structural biology has emerged as a major tool for the design of novel vaccine antigens. Here, we review the important contributions that protein crystallography has made so far to vaccine research and de...
We present a crystallography chip enabling in situ room temperature crystallography at microfocus synchrotron beamlines and X-ray free-electron laser (X-FEL) sources. Compared to other in situ approaches, we observe extremely low background and high diffraction data quality. The chip design is robust and allows fast and efficient loading of thousands of small crystals. The ability to load a lar...
The history of crystallography has been assessed in the context of the emergence and spread of the molecular theory. The present paper focuses on the 19th century, which saw the emancipation of crystallography as a science sui generis. Around 1800, Laplace’s molecularism called the tune in the various sciences (physics, chemistry, biology, crystallography). In crystallography, two schools oppos...
While protein crystallography has, for many years, been the most used method for structural analysis of macromolecular complexes, remarkable recent advances in high-resolution electron cryo-microscopy led to suggestions that 'the revolution will not be crystallised'. Here we highlight the current success rate, speed and ease of modern crystallographic structure determination and some recent tri...
Complete automation of the macromolecular crystallography experiment has been achieved at SSRL through the combination of robust mechanized experimental hardware and a flexible control system with an intuitive user interface. These highly reliable systems have enabled crystallography experiments to be carried out from the researchers' home institutions and other remote locations while retaining...
The study of the isoperimetric problem in the presence of crystallographic symmetries is an interesting unsolved question in classical differential geometry: Given a space group G, we want to describe, among surfaces dividing Euclidean 3-space into two G-invariant regions with prescribed volume fractions, those which have the least area per unit cell of the group. We know that this periodic iso...
We have investigated the nuclear density distributions in LaGaO3based perovskites, LaGaO3 (LG), (La0.9Sr0.1)GaO3(LSG), La(Ga0.9Mg0.1)O3(LGM), and (La0.8Sr0.2)(Ga0.8Mg0.15Co0.05)O3(LSGMC), to elucidate the ionic conduction path and disorder of oxide ions at elevated temperatures. Neutron diffraction data were collected in the temperature range from 26 to 1405oC in air, using a diffractometer HER...
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