This study considers a combination of cross-docking and vehicle routing problem (VRP) approachesto transport raw material and parts in a supply chain. The supply chain is composed of some supplierswhich are spread in different geographical zones and multiple shared vehicles with different speedsand capacities for transporting orders from the suppliers to a manufacturer. After ...

Nowadays, cross-docking is one of the main concepts in supply chain management in which products received to a distribution center by inbound trucks which are directly to lead into outbound trucks with a minimum handling and storage costs as the main cost of a cross-docking system. According to the literature, several metaheuristics and heuristics are attempted to solve this optimization model....

Mathematical modeling of supply chain operations has proven to be one of the most complex tasks in the field of operations management and operations research. Despite the abundance of several modeling proposals in the literature; for vast majority of them, no effective universal application is conceived. This issue renders the proposed mathematical models inapplicable due largely to the fact th...

SKATE is a docking prototype that decouples systematic sampling from scoring. This novel approach removes any interdependence between sampling and scoring functions to achieve better sampling and, thus, improves docking accuracy. SKATE systematically samples a ligand's conformational, rotational and translational degrees of freedom, as constrained by a receptor pocket, to find sterically allowe...

The objective of this study is to identify novel HIV-1 integrase (IN) inhibitors. Here, shape-based screening and QSAR have been successfully implemented to identify the novel inhibitors for HIV-1 IN, and in silico validation is performed by docking studies. The 2D QSAR model of benzodithiazine derivatives was built using genetic function approximation (GFA) method with good internal (cross-val...

Quantitative structure-activity relationship and molecular docking studies were carried out on a series of quinazolinonyl analogues as anticonvulsant inhibitors. Density Functional Theory (DFT) quantum chemical calculation method was used to find the optimized geometry of the anticonvulsants inhibitors. Four types of molecular descriptors were used to derive a quantitative relation between anti...

In this research, a truck scheduling problem for cross-docking system with multiple receiving and shipping docks is studied. Until recently, single-dock problems are studied mostly. This research focused on the multiple-dock problems. The objective of to determine best docking sequences inbound outbound trucks docks, respectively, which minimize maximal completion time. We propose new hybrid ge...

AIM To understand pharmacophore properties of styrylquinoline derivatives and to design inhibitors of HIV-1 integrase. METHODS Comparative molecular field analysis (CoMFA) was performed to analyze three-dimensional quantitative structure-activity relationship (3D-QSAR) of styrylquinoline derivatives. Thirty-eight compounds were randomly divided into a training set of 28 compounds and a test s...