REPORTING INFORMATION  Class B2: Report by the end of the business week in which the case or suspected case presents and/or a positive laboratory result to the local public health department where the patient resides. If patient residence is unknown, report to the local public health department in which the reporting health care provider or laboratory is located.  Reporting Form(s) and/or Mec...

Starting out from a case report about a 84-year-old woman changing from absolute inconspicuousness to complete senile dementia within a few months, the authors present a not very well known neuropsychiatric disorder: the Jakob-Creutzfeldt disease. In short, historical, morphological and symptomatological aspects and laboratory findings are discussed, and it is shown that the complex problem of ...

Accessible online at: www.karger.com/ene Creutzfeldt-Jakob disease (CJD) is a transmissible spongiform encephalopathy. It is characterised pathologically by neuronal loss, spongy changes in the grey matter and an astrocytosis, and clinically by rapidly progressing dementia, pyramidal and extrapyramidal disease with myoclonus and triphasic discharges in the electroencephalogram. This dreaded fat...

The possibility of the age-related reemergence of foodborne Mycobacterium bovis (bovine tuberculosis) as a vector for Creutzfeldt-Jakob Disease (CJD or human Mad Cow Disease) and Mad Cow disease itself is real. The CDC reported last May of an outbreak of CJD linked to the consumption of meat contaminated "with the agent causing" bovine spongiform encephalopathy (BSE) in a New Jersey racetrack b...

OBJECTIVE To compare conventional and diffusion-weighted MR imaging in terms of their depiction of the abnormalities occurring in Creutzfeldt-Jakob disease. MATERIALS AND METHODS We retrospectively analyzed the findings of conventional (T2-weighted and fluid-attenuated inversion recovery) and diffusion-weighted MR imaging in four patients with biopsy-proven Creutzfeldt-Jakob disease. The sign...

Differentiating demyelinating conditions from neoplastic conditions can pose a significant challenge. There are a number of reports in the literature of large ring-enhancing, space-occupying lesions that were initially considered neoplastic or infectious but, on further review, were deemed demyelinating. Creutzfeldt-Peters cells (CPC) are reactive astrocytes with fragmented nuclear inclusions t...

BACKGROUND Differential diagnosis of severe progressive dementia includes a wide spectrum of inflammatory and neurodegenerative diseases. Particularly challenging is the differentiation of potentially treatable autoimmune encephalitis and Creutzfeldt-Jakob disease. Such a coincidence may indeed complicate the correct diagnosis and influence subsequent treatment. CASE PRESENTATION A 75-year-ol...

OBJECTIVE To report the clinical and neuropathological features in a patient with Creutzfeldt-Jakob disease with amyotrophy and demyelinating polyneuropathy. DESIGN Case report. PATIENT AND RESULTS A 62-year-old man had progressive numbness of the left foot, unsteady gait, diminished deep reflexes, fasciculations, and tactile hypesthesia on the feet. Cerebrospinal fluid, electroneurography,...

Despite the fact that cartilage, cortical bone and corneal homograft tissue is still widely used in South Africa and that there has never been a reported case of human immunodeficiency virus or Creutzfeldt-Jakob disease infection transmission via this route, otolaryngologists are still reluctant to use homograft ossicles. In third world countries, such as South Africa, where ossicular prosthese...