from serial changes in plasma creatine phosphokinase activity. Acta Med Scand 587: 151-166, 1975 13. Roberts R, Sobel BE: Effect of selected drugs and myocardial infarction on the disappearance of creatine kinase from the circulation in conscious dog. Cardiovasc Res 11: 103-112, 1977 14. Sobel BE, Shell WE, Klein MS: An isoenzyme of creatine phosphokinase associated with rabbit heart mitochondr...

OBJECTIVES In this study, we aimed at evaluation of electrophysiological and histopathalogical characteristics of statin-induced muscle injury as well as clinical features of patients who develop this condition in terms of frequency and pattern of evolution. MATERIALS AND METHODS Forty patients (age 39-74 years) including 25 subjects with type 2 diabetes mellitus, 9 with cardiovascular diseas...

A 71-year-old male who had a bile-duct cancer with liver metastases underwent systemic chemotherapy with cisplatin (25 mg/m) followed by gemcitabine (GC) (1000 mg/m). Two days after the first administration, he complained of ‘crampy’ abdominal pain. White blood cell count and levels of C-reactive protein and liver enzymes were elevated but those of creatine phosphokinase and lactate Figure 1. J...

Hypocalcemic cardiomyopathy is a rare entity. We describe a patient with severe heart failure, decreased ejection fraction and global hypokinesia documented on echocardiogram, associated with severe hypocalcemia, very low vitamin D status, increased QT intervals, increased BNP (serum brain natriuretic peptide) levels and CPK (creatine phosphokinase) levels. All these defects reversed on treatme...

A transient but considerable rise in serum creatine phosphokinase (CPK) levels occurred in six boys aged between 8 and 11 years and suffering from phenothiazine-induced dystonia. In one boy (Case 4), after the CPK level had returned to normal after withdrawal of the drug, its reintroduction orally at lower dosage caused a slight increase in the level of CPK in the absence of any recurrence of t...

A 49-year-old woman presented in fulminant hepatic failure. The ECG showed dramatic ST-segment elevation, suggesting diffuse myocardial injury. However, echocardiography, creatine phosphokinase enzyme determinations, and examination of the heart at autopsy (six days later) failed to demonstrate any physiologic, anatomic, or histologic evidence of abnormality. The appearance of ST-segment elevat...

Cardiac arrest occurred in a 5 1/2-year-old child with suspected Duchenne's muscular dystrophy ten minutes following induction of anaesthesia with halothane, nitrous oxide and oxygen. No muscle relaxants were administered. The cardiac arrest was associated with hyperkalaemia, acidosis, myoglobinuria, elevated serum creatine phosphokinase and a 1.6 degrees C rise in temperature. The child made a...