BACKGROUND The purpose of this study is to review late toxicity following craniospinal radiation for early-stage medulloblastoma. MATERIAL AND METHODS Between 1963 and 2008, 53 children with stage M0 (n = 50) or M1 (n = 3) medulloblastoma were treated at our institution. The median age at diagnosis was 7.1 years (range 1.2-18.5). The median craniospinal irradiation (CSI) dose was 28.8 Gy (ran...

Hemangioblastomas are rare and benign tumors accounting for less than 2% of all central nervous system (CNS) tumors. The vast majority of hemangioblastomas occur sporadically, whereas a small number of cases, especially in younger patients, are associated with Von Hippel-Lindau (VHL) syndrome. It is thought that loss of tumor suppressor function of the VHL gene results in stabilization of hypox...

Medulloblastoma (MB) is the most frequent malignant brain tumor in children. Treatment of MB based on histopathological and molecular stratification, includes surgical intervention, often with craniospinal irradiation adjuvant chemotherapy. Unfortunately, however, this treatment leads to a high morbidity rate, it does not cure all patients either, around 30% succumbing their disease. With impro...

Pilocytic astrocytoma (PA) is a low grade benign tumor, commonly occurs in Cerebellum (42-60%), Optic & hypothalamic region (9-30%), Brain Stem (9%). They rarely spread. It within the ventricle. In this report, we described our experience with cranial pilocytic 14-year-old child, who initially treated near total decompression of tumor. Four and half years later, recurrence primary tumor obs...