نتایج جستجو برای: cox transformation

تعداد نتایج: 269166  

2011
Marcos Vinícius Gualberto Barbosa da Silva Curtis P. Van Tassell Tad S. Sonstegard Jaime Araujo Cobuci Louis C. Gasbarre

Accurate genetic evaluation of livestock is based on appropriate modeling of phenotypic measurements. In ruminants, fecal egg count (FEC) is commonly used to measure resistance to nematodes. FEC values are not normally distributed and logarithmic transformations have been used in an effort to achieve normality before analysis. However, the transformed data are often still not normally distribut...

SK Kulkarni SSV Padi

Despite the important role of both cyclooxygenase (COX) isoforms (i.e. COX-1 and COX-2) in maintenance of hypersensitivity following peripheral nerve injury, their role in the development of neuropathic pain is not clear. The present study was undertaken to determine the effect of COX inhibitors to address the potential role of COX isozymes in the development of neuropathic pain in rats after c...

A new group of 4-(Imidazolylmethyl) quinoline derivatives possessing a methylsulfonyl COX-2 pharmacophore at the para position of the C-2 phenyl ring were designed and synthesized as selective COX-2 inhibitors and in-vitro anti breast cancer agents. In-vitro COX-1 and COX-2 inhibition studies showed that all the compounds were potent and selective inhibitors of the COX-2 isozyme with IC50 value...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2001
K Yoshimatsu N K Altorki D Golijanin F Zhang P J Jakobsson A J Dannenberg K Subbaramaiah

An inducible microsomal form of human prostaglandin E synthase (mPGES) was recently identified. This enzyme converts the cyclooxygenase (COX) product, prostaglandin (PG) H2, to PGE2, a prostanoid that has been implicated in carcinogenesis. Increased amounts of PGE2 are detected in many types of cancer, but the underlying mechanism is not fully understood. Hence, we compared amounts of mPGES in ...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000
R Zeidler M Csanady O Gires S Lang B Schmitt B Wollenberg

The cyclooxygenases (COX)-1 and COX-2 are key enzymes in the conversion of arachidonic acid to prostaglandins and other eicosanoids. Whereas COX-1 is expressed ubiquitously, COX-2 is an immediate-early gene often associated with malignant transformation, and a role for the COX enzymes in tumor initiation and promotion is discussed. Nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin and ...

Journal: :Journal of Nonlinear Mathematical Physics 2021

We consider some well-known partial differential equations that arise in Financial Mathematics, namely the Black–Scholes–Merton, Longstaff, Vasicek, Cox–Ingersoll–Ross and Heath equations. Our central aim is to discover any underlying connections taking into account Lie remarkability property of heat equation. For a few these there known connection with equation through coordinate transformatio...

Journal: :journal of pharmaceutical and health sciences 0

a group of 1,3-biarylhydrazide derivatives possessing a cox-2 azido pharmacophore at the para- position of the c-1 phenyl ring in conjunction with a n-3 phenyl or substituted-phenyl ring (4-f,4-cl,4-ome) were designed and synthesized based on nucleophilic substitution reaction. a molecular modelling study of these compounds showed that the designed molecules were well bound with the active site...

Journal: :Kybernetika 2009
Beáta Stehlíková Daniel Sevcovic

In this paper we are interested in term structure models for pricing zero coupon bonds under rapidly oscillating stochastic volatility. We analyze solutions to the generalized Cox–Ingersoll-Ross two factors model describing clustering of interest rate volatilities. The main goal is to derive an asymptotic expansion of the bond price with respect to a singular parameter representing the fast sca...

Journal: :J. Applied Mathematics 2013
Edward Chi-Fai Lo

The Lie-algebraic approach has been applied to solve the bond pricing problem in single-factor interest rate models. Four of the popular single-factor models, namely, the Vasicek model, Cox-Ingersoll-Ross model, double square-root model, and Ahn-Gao model, are investigated. By exploiting the dynamical symmetry of their bond pricing equations, analytical closed-form pricing formulae can be deriv...

2005
Helen W. Belding N. C. Conrad Maier Robert B. Chodos Charles E. Rath Jean P. Soulier Timothy R. Talbot

JOSEPH F. Ross, M.D., Editor

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