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The piecewise-constant exponential model is a semi-parametric continuous time duration model.1 The model is semi-parametric in the sense that the shape of the hazard rate with respect to time is not specified a priori but is determined by the data. The basic idea underlying the PCE model is that the duration time can be divided up into discrete units in each of which the hazard rate is assumed ...

A new series of imidazo[2,1-b]thiazole analogs containing a methyl sulfonyl COX-2 pharmacophore was synthesized and evaluated for their COX-2 inhibitory activity. According to in-vitro COX-1/COX-2 inhibition data, all compounds (6a-g) were selective inhibitors of COX-2 isoenzyme with IC50 values in the highly potent 0.08-0.16 mM range. These results indicated that both potency and selectivity o...

a substantial amount of evidence has proposed an important role for cyclooxygenase-2 (cox-2) enzyme in brain diseases and affiliate disorders. the purpose of this research was studying the effects of cox-2 selective inhibition on haloperidol-induced catatonia in an animal model of drug overdose and parkinson’s disease (pd). in this study, the effect of acute and sub-chronic oral administration ...

Finbarr Department ofI:sio~;tatisti(;s University of 'Wa:5hirlgtcm Seattle. WA

The Cox (1972) regression model is extended to include discrete and mixed continuous/discrete failure time data by retaining the multiplicative hazard rate form of the absolutely continuous model. Application of martingale arguments to the regression parameter estimating function show the Breslow(1974) estimator to be consistent and asymptotically Gaussian under this model. A computationally co...

In this paper we show that the order of convergence of the semi discrete numerical scheme that we have proposed before to approximate the CIR process is tending to be one as ∆ → 0.

The Ross-Macdonald Model We use the following simple version of the Ross-Macdonald model. The parameters are described in Box #1. For a longer explanation, see [1]. The change in the PR, the prevalence of infection, is given by the equation: ˙ X = mabZ(1 − X) − rX (1) The change in the sporozoite rate, the fraction of the mosquitoes with sporozoites in their salivary glands, is modeled using th...