نتایج جستجو برای: cox 2 inhibitory

تعداد نتایج: 2641865  

Journal: :The Journal of pharmacology and experimental therapeutics 2000
C Boulos H Jiang M Balazy

Peroxynitrite (ONOO(-)), a reactive oxidant produced by the reaction between nitric oxide and superoxide, was found to diffuse into the platelet cytosol and inhibit arachidonic acid-induced platelet aggregations with IC(50) value of 5.8 +/- 1.2 microM. A fluorescence assay established that ONOO(-) diffused into the platelet cytosol in a manner that was inhibited (50-70%) by 4, 4'-diisothiocyana...

Journal: :Cancer research 2006
Takiko Daikoku Susanne Tranguch Irina N Trofimova Daniela M Dinulescu Tyler Jacks Alexander Yu Nikitin Denise C Connolly Sudhansu K Dey

Cyclooxygenases-1 and -2 (Cox-1 and Cox-2) are two distinct isoforms that catalyze the conversion of arachidonic acid to prostaglandins. The role of Cox-2 in a variety of cancers is well recognized, but the contribution of Cox-1 remains much less explored. We have previously shown that human epithelial ovarian tumors have increased levels of Cox-1, but not Cox-2. We also observed that Cox-1 is ...

Journal: :Journal of agricultural and food chemistry 2007
Vanisree Mulabagal Steven Van Nocker David L Dewitt Muraleedharan G Nair

The red coloration of apple skin is mainly due to anthocyanins that are reported to possess health benefits. The aim of the present study was to determine the anthocyanin content in three underutilized Malus pumila Mill cultivars, Cranberry, Kerr, and Niedzwetzkyana, and confirm their anti-inflammatory and antioxidant activities. Our analysis revealed that the three cultivars studied contained ...

Journal: :Mediators of Inflammation 2005
Riina Nieminen Sari Leinonen Aleksi Lahti Katriina Vuolteenaho Ulla Jalonen Hannu Kankaanranta Mary B. Goldring Eeva Moilanen

Inducible prostaglandin synthase (cyclooxygenase-2, COX-2) is expressed in rheumatoid and osteoarthritic cartilage and produces high amounts of proinflammatory prostanoids in the joint. In the present study we investigated the effects of the inhibitors of mitogen-activated protein kinase (MAPK) pathways Erk1/2, p38, and JNK on COX-2 expression and prostaglandin E2 (PGE2) production in human cho...

2010
Kyoung Sik Park Bong Hyun Kim Il-Moo Chang

To verify the anti-inflammatory potency of iridoids, seven iridoid glucosides (aucubin, catalpol, gentiopicroside, swertiamarin, geniposide, geniposidic acid and loganin) and an iridoid aglycone (genipin) were investigated with in vitro testing model systems based on inhibition of cyclooxygenase (COX)-1/-2 enzymes, the tumor necrosis factor-α (TNF-α) formation and nitric oxide (NO) production. ...

2016

Aspirin (Acetylsalicylic acid) was introduced to treating human more than 100 years ago [1] due to its anti-inflammatory and anti-pyretic benefits it is widely used in clinical settings. First of all it was reported by [2] that aspirin and non-steroidal antiinflammatory drugs inhibit the synthesis of pro-inflammatory prostaglandin E2.lattor on it was reported that aspirin has inhibitory effect ...

2005
RODERICK J. FLOWER JOHN R. VANE

Constitutive cyclooxygenase (COX-1; prostaglandin-endoperoxide synthase, EC 1.14.99.1) is present in cells under physiological conditions, whereas COX-2 is induced by some cytokines, mitogens, and endotoxin presumably in pathological conditions, such as inflammation. Therefore, we have assessed the relative inhibitory effects of some nonsteroidal antiinflammatory drugs on the activities of COX-...

Journal: :Gut 2000
B J Whittle

Despite the considerable range of newly identified disease modifying approaches to the control of the inflammatory process reported over the past 10–20 years, only a few have yet gained widespread clinical acceptance. In contrast, the very recent advent of the class of anti-inflammatory agents termed COX-2 selective inhibitors is already having a significant impact on current clinical prescribi...

Cyclooxygenase-2 (COX-2) has a pivotal role in the pathogenesis of the lung cancer. It is known that COX-2 negatively regulates the activity of a number of tumor suppressors, including p53. Consequently, inhibition of COX-2 signaling is anticipated to be a promising approach to stabilize p53 functionality. In this regard, we investigated the effect of COX-2 signaling blockade on p53 and COX-2 e...

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